Safety and feasibility of cerebrolysin in treatment of primary intracerebral hemorrhage (CLINCH)—a prospective, randomized, open-label, blinded endpoint pilot trial

This trial addresses critical limitations of previous ICH neuroprotection studies by focusing on lobar hemorrhages, implementing an ultra-early treatment window (≤6 h), and combining neuroprotection with intensive rehabilitation. The restrictive eligibility criteria may limit generalizability but enhance the likelihood of detecting treatment effects. If positive, results would support a larger confirmatory trial and inform the sample size.