FGF4 drives tumor progression in triple-negative breast cancer via IL6/STAT3-mediated macrophage M2 polarization and immune suppression
FGF4 promotes TNBC progression by activating IL6/STAT3 to reprogram macrophages into immune-suppressive M2 effectors, fostering a tumor-permissive microenvironment. Targeting FGF4 may disrupt this crosstalk, offering a novel immunotherapeutic strategy for TNBC.
Authors
- Shushan Zhang (ORCID: https://orcid.org/0000-0003-2401-6587)
- Xuanhe Zhang
- Yuanyuan Han (ORCID: https://orcid.org/0000-0002-8843-6073)
Institutions
- Sun Yat-sen University (CN)
- Zhuhai People's Hospital (CN)
- Fifth Affiliated Hospital of Sun Yat-sen University (CN)
- Weihai Maternal and Child Health Hospital (CN)
Publication Details
- Journal
- Cell Division
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1186/s13008-025-00164-y
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00