Immunoproteasome Inhibition Positively Impacts the Gut‐Muscle Axis in Duchenne Muscular Dystrophy
Our study advances the understanding of the role of dysbiosis in DMD disease and identifies IP inhibition as a potential therapeutic strategy to modulate the dystrophic gut-muscle axis, offering new perspectives for microbiota-targeted therapies.
Authors
- Mattia Bolzan (ORCID: https://orcid.org/0000-0001-8539-9468)
- Yvan Torrente (ORCID: https://orcid.org/0000-0002-2705-3984)
- Luana Tripodi (ORCID: https://orcid.org/0000-0003-4446-2840)
- Barbara Cassani (ORCID: https://orcid.org/0000-0002-4115-8109)
- Francesco Fortunato (ORCID: https://orcid.org/0000-0001-8395-7809)
- Annamaria Landolfi (ORCID: https://orcid.org/0000-0002-4975-4722)
- Andrea Farini (ORCID: https://orcid.org/0000-0002-8514-4921)
- Francesco Strati (ORCID: https://orcid.org/0000-0001-7217-3355)
- Aitor Blanco‐Míguez (ORCID: https://orcid.org/0000-0001-7386-5572)
- Davide Bazzani (ORCID: https://orcid.org/0000-0002-2254-651X)
- Federica Facciotti (ORCID: https://orcid.org/0000-0002-2541-9428)
- Flavio Caprioli (ORCID: https://orcid.org/0000-0002-8077-8175)
- Jacopo Troisi (ORCID: https://orcid.org/0000-0003-2962-7379)
- Monica L. Molinaro (ORCID: https://orcid.org/0000-0002-5629-5974)
- Debora Mostosi (ORCID: https://orcid.org/0009-0008-8032-6321)
- Sabrina Saccone (ORCID: https://orcid.org/0009-0005-1119-8790)
- Chiara Amoroso (ORCID: https://orcid.org/0000-0002-5987-7582)
- Emma Leonetti
Institutions
- University of Salerno (IT)
- University of Milan (IT)
- University of Trento (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Ferrari (Italy) (IT)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/jcsm.70054
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Università degli Studi di Milano
- Dipartimenti di Eccellenza
- Fondazione Cariplo
- Ministero della Salute
- Fondazione Regionale per la Ricerca Biomedica
- Centers for Disease Control and Prevention