Fat Mass and Obesity-Associated Protein-Mediated Adipogenic Differentiation of Bone Marrow Mesenchymal Stem Cells Promotes Chemotherapy Resistance in Acute Myeloid Leukemia
FTO enhances adipogenic differentiation of CR-AML-MSCs through m<sup>6</sup>A demethylation of raptor, leading to mTORC1 pathway activation and subsequent chemoresistance. These findings reveal a novel mechanism underlying AML chemoresistance and suggest potential therapeutic targets.
Authors
- Zhipeng Pan (ORCID: https://orcid.org/0000-0002-6630-6163)
- Ling Chen (ORCID: https://orcid.org/0000-0003-4557-0149)
- Kang Lixia (ORCID: https://orcid.org/0000-0003-3094-6211)
Institutions
- Fujian Medical University (CN)
- Fuzhou Second Hospital (CN)
- Union Hospital (CN)
- Fujian University of Technology (CN)
Publication Details
- Journal
- Balkan Medical Journal
- Published
- 2025-10-02
- DOI
- https://doi.org/10.4274/balkanmedj.galenos.2025.2025-7-150
- Primary Topic
- Bone and Joint Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00