Gene variants of glucocorticoid activation pathways and the outcomes of patients with Takayasu arteritis – a retrospective cohort study
Worsening glucose tolerance and the carriage of 9β of the <i>NR3C1</i> gene were independent risk factors for acute ischemic events in TAK. The 9β polymorphism of the <i>NR3C1</i> gene was associated with GC-related AEs in TAK in our patient population. None of the gene variants were predictors of sustained remission or arterial progression.
Authors
- E.B. Zarur (ORCID: https://orcid.org/0000-0002-1057-2104)
- Alexandre Wagner Silva de Souza (ORCID: https://orcid.org/0000-0001-7681-6215)
- Gerson Dierley Keppeke (ORCID: https://orcid.org/0000-0003-0660-2857)
- Faustino Peron Filho
- Andressa de Souza Moreira
Institutions
- Universidad Católica del Norte (CL)
- Universidade do Estado do Rio de Janeiro (BR)
- Universidade Federal do Estado do Rio de Janeiro (BR)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1675026
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo