Genetic and serum biomarkers of NSAID hypersensitivity reactions
Our study highlights a significant association between SNVs in genes related to the vitamin D pathway, retinoid receptors and the high-affinity IgE receptor with the risk of NSAIDs HRs. Additionally, the correlation between IgE levels and clinical phenotypes suggests a potential role for this biomarker in the pathophysiology and stratification of these reactions.
Authors
- Gemma Amo (ORCID: https://orcid.org/0000-0002-1505-8163)
- Natalia Blanca‐López (ORCID: https://orcid.org/0000-0002-1492-9887)
- Elena Garcı́a-Martı́n (ORCID: https://orcid.org/0000-0002-8094-046X)
- G. Canto
- José A. G. Agúndez (ORCID: https://orcid.org/0000-0001-6895-9160)
- Pedro Ayuso (ORCID: https://orcid.org/0000-0002-9441-4022)
- J.A. Cornejo‐García (ORCID: https://orcid.org/0000-0003-3465-8735)
- Javier Gómez‐Tabales (ORCID: https://orcid.org/0000-0002-8044-1601)
- I. Doña
- Manuel Martí (ORCID: https://orcid.org/0000-0002-2977-1357)
- Marı́a José Torres (ORCID: https://orcid.org/0000-0001-5228-471X)
- Jesús Miguel García-Menaya
- M. Blanca
Institutions
- Hospital Regional Universitario de Málaga (ES)
- Centro de Implantología Cirugía Oral y Maxilofacial (ES)
- Andalusian Centre for Nanomedicine and Biotechnology (ES)
- Instituto de Investigación Biomédica de Málaga (ES)
- Hospital Universitario Infanta Leonor (ES)
- Universidad de Extremadura (ES)
- Universidad de Málaga (ES)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-02
- DOI
- https://doi.org/10.3389/fphar.2025.1502755
- Citations
- 1
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- European Commission
- Junta de Extremadura
- Instituto de Salud Carlos III