CHMP4A in hepatocellular carcinoma: exploring its role in tumor progression, immune modulation, and potential link to TIM3 checkpoint
Our extensive analyses identified CHMP4A as a critical molecular determinant in the progression of LIHC, which may function through two oncogenic mechanisms: the promotion of tumor cell proliferation and metastatic potential, and immunomodulatory effects associated with the TIM3/LGALS9 signaling pathway. These findings indicated that CHMP4A might serve as a potential therapeutic target and prognostic biomarker in LIHC.
Authors
- Song Wen (ORCID: https://orcid.org/0000-0001-6173-0507)
- Kai Sun (ORCID: https://orcid.org/0000-0001-9619-9007)
- Kongjia Wang (ORCID: https://orcid.org/0009-0002-0995-409X)
- Shuangping Guo (ORCID: https://orcid.org/0000-0001-6389-9568)
- Qinghua Pan (ORCID: https://orcid.org/0000-0002-0767-4089)
Institutions
- Ganzhou People's Hospital (CN)
- Gannan Medical University (CN)
- First Affiliated Hospital of Gannan Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1682724
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00