Patterns of restricted TCR usage following SARS-CoV-2 vaccination and severe disease
Overarchingly, TCR repertoire analysis revealed that CD8 T cells responding to SARS-CoV-2 broadly recognize epitopes across the SARS-CoV-2 proteome, and provided opportunities to identify epitopes associated with disease.
Authors
- Brian K. Agan (ORCID: https://orcid.org/0000-0002-5114-1669)
- Nusrat J Epsi (ORCID: https://orcid.org/0000-0001-5363-075X)
- Stephanie A Richard (ORCID: https://orcid.org/0000-0002-0530-384X)
- Clifton L. Dalgard (ORCID: https://orcid.org/0000-0003-2025-8239)
- Zhongyan Lu (ORCID: https://orcid.org/0000-0001-9898-0710)
- Katrin Mende
- Camille Alba (ORCID: https://orcid.org/0000-0002-0458-1629)
- Catherine M Berjohn (ORCID: https://orcid.org/0000-0001-5655-8183)
- Emily Parsons
- Simon Pollett (ORCID: https://orcid.org/0000-0002-4450-7028)
- John Rosenberger (ORCID: https://orcid.org/0000-0003-2914-6727)
- Rhonda E Colombo (ORCID: https://orcid.org/0000-0003-0154-1928)
- David A Lindholm (ORCID: https://orcid.org/0000-0001-5428-7404)
- Jennifer Lê (ORCID: https://orcid.org/0000-0002-6692-0884)
- Gauthaman Sukumar (ORCID: https://orcid.org/0000-0003-3129-4171)
- Allison M. W. Malloy (ORCID: https://orcid.org/0000-0003-2962-0302)
- Phuong Nguyen
- David R. Tribble (ORCID: https://orcid.org/0000-0003-3077-9505)
- Amanda E Zelkoski
- Xijun Zhang (ORCID: https://orcid.org/0009-0002-8434-5673)
- Timothy H. Burgess
- Naraen Palanikumar
Institutions
- Henry M. Jackson Foundation (US)
- Naval Medical Center San Diego (US)
- Madigan Army Medical Center (US)
- Uniformed Services University of the Health Sciences (US)
- Joint Base San Antonio (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1576903
- Citations
- 1
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Uniformed Services University of the Health Sciences