3KO-NSCs ameliorate behavioral deficits and modulate gut microbiota in a VPA-induced C57BL/6 mouse model of autism
3KO-NSCs exert dual therapeutic effects by mitigating central neuroinflammation and rebalancing gut microbiota. This provides the first direct evidence that stem cell therapy can modulate the gut-brain axis to treat ASD, positioning 3KO-NSCs as a novel bifunctional therapeutic strategy.
Authors
- Yang Xiao-ya (ORCID: https://orcid.org/0000-0002-6414-8413)
- Caixia Wu
- Zhaoming Liu (ORCID: https://orcid.org/0000-0001-9146-4502)
- Xianjie Li (ORCID: https://orcid.org/0000-0002-2749-5352)
- Handong Wang (ORCID: https://orcid.org/0000-0001-5989-9338)
Institutions
- Guangzhou Institutes of Biomedicine and Health (CN)
- Guangdong Academy of Sciences (CN)
- Guangzhou Vocational College of Science and Technology (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1680179
- Citations
- 2
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 2.86