Oxymatrine inhibited the progression of renal cell carcinoma by increasing TOR1AIP1 expression
Our findings demonstrate that OMT suppresses RCC progression by increasing the expression of TOR1AIP1 and inactivating the JNK signaling pathway. These findings support TOR1AIP1 as a mechanistic mediator of OMT's antitumor effects in RCC models and provide a rationale for further evaluation in physiologically relevant <i>in vivo</i> systems and with formal pharmacokinetic and toxicity studies.
Authors
- Tianzhen He (ORCID: https://orcid.org/0000-0001-7873-853X)
- Xinbao Yin (ORCID: https://orcid.org/0000-0002-4934-4037)
- Zongliang Zhang
- Xuechuan Yan
- Ke Wang (ORCID: https://orcid.org/0000-0002-1866-0678)
- Zaiqing Jiang
- Kai Shu (ORCID: https://orcid.org/0000-0002-7275-7315)
- Yang Han (ORCID: https://orcid.org/0000-0001-6249-370X)
Institutions
- Qingdao University (CN)
- Weifang Medical University (CN)
- Nantong University (CN)
- Affiliated Hospital of Qingdao University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-02
- DOI
- https://doi.org/10.3389/fphar.2025.1611069
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China