SPP1+macrophages promote fibroblast-to-myofibroblast transformation during hypoxia in deep fascia of acute compartment syndrome
Hypoxia induces SPP1+macrophages, which in turn activate fibroblasts, driving myofibroblast transformation in ACS. Targeting this pathway may provide a potential therapeutic strategy for mitigating fibrosis and improving outcomes in ACS.
Authors
- Zihang Zhao (ORCID: https://orcid.org/0000-0001-6351-1180)
- Juan Cao (ORCID: https://orcid.org/0000-0002-4333-2991)
- Zhiyong Hou (ORCID: https://orcid.org/0000-0001-5838-4025)
- Qi Dong
- Liujie Zheng (ORCID: https://orcid.org/0000-0002-9223-8782)
- Guoqiang Li (ORCID: https://orcid.org/0000-0002-7004-6659)
- Haofei Wang (ORCID: https://orcid.org/0000-0001-8914-442X)
Institutions
- Hebei Medical University (CN)
- Ministry of Education of the People's Republic of China (CN)
- National Health and Family Planning Commission (CN)
- Third Hospital of Hebei Medical University (CN)
- Hospital of Hebei Province (CN)
- Hebei Science and Technology Department (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1588926
- Citations
- 1
- Primary Topic
- Muscle and Compartmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.01