Integrative multidimensional analysis of age-associated synthetic lethal genes and development of a prognostic model in breast cancer
Age-associated SL genes play critical roles in BRCA, with SLC7A5 highlighted as a promising biomarker and therapeutic target. These findings provide insights for early diagnosis and metabolism-based precision therapy.
Authors
- Dongxu Ma
- Xiang Wang (ORCID: https://orcid.org/0000-0002-5211-7206)
- Wenjuan Zhang (ORCID: https://orcid.org/0000-0001-6972-6449)
- Wenbing Zhang (ORCID: https://orcid.org/0000-0001-8553-6565)
- Qinqing Wu
- Heng Cao (ORCID: https://orcid.org/0000-0002-4385-7958)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fudan University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- Shantou University (CN)
- National Cancer Center (US)
- Shantou University Medical College (CN)
- Zhongshan Hospital (CN)
- Anqing City Hospital (CN)
- Beijing Chaoyang Emergency Medical Center (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1690301
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Anhui Medical University