Unbiased kinome profiling identifies key and novel mediators of chronic kidney disease in hyperlipidemic mice

These findings highlight critical kinases involved in CKD development and suggest their potential roles in mediating pathological processes such as inflammation and fibrosis. Targeting specific kinases may offer novel therapeutic strategies for mitigating CKD progression and its cardiovascular complications. Future research should explore the causal relationships between newly identified kinases and CKD development.