Dual roles of in situ generated HSP70 in antigen delivery and immunoregulation
These results indicate dual roles of <i>in situ</i> induced HSP70 in antigen delivery and immunoregulation at physiological conditions. These dual functions highlight opportunities to exploit endogenous HSP70 for both vaccine adjuvantation and immunomodulation.
Authors
- Xinliang Kang
- Zhuofan Li (ORCID: https://orcid.org/0000-0002-7267-7059)
- Jayachandra Reddy Nakkala
- Xinyuan Chen (ORCID: https://orcid.org/0000-0003-4735-3922)
- Yibo Li (ORCID: https://orcid.org/0000-0002-9640-4493)
- Labone Akter
- Yiwen Zhao
Institutions
- University of Rhode Island (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1638948
- Primary Topic
- Heat shock proteins research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of General Medical Sciences