Transepidermal water loss increases during murine food anaphylaxis and reflects reaction severity
TEWL is reliably measured on the mouse ear. TEWL increased under varied reaction conditions, and the stimulus used did not alter results. TEWL offers a novel, real-time, objective, and noninvasive measure of murine food anaphylaxis that corresponds to human pathophysiology.
Authors
- Benjamin N. Woerner
- JE Hines
- Simon P. Hogan (ORCID: https://orcid.org/0000-0001-5793-4304)
- James R. Baker (ORCID: https://orcid.org/0000-0002-4478-1932)
- Charles F. Schuler (ORCID: https://orcid.org/0000-0001-5656-7418)
- Jessica J. O’Konek (ORCID: https://orcid.org/0000-0002-1455-0586)
- Marie Collins Donahue
- Allison Wang (ORCID: https://orcid.org/0009-0009-8734-8109)
- Joseph Abbo
Institutions
- University of Michigan (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1667569
- Primary Topic
- Food Allergy and Anaphylaxis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health