Predictive gene expression signatures for Alzheimer’s disease using post-mortem brain tissue
Molecular signatures underlying regional vulnerability to AD provide a framework for understanding genetic and systemic factors in disease progression. Findings highlight specific molecular pathways, including ECM-related processes and hormonal regulation, as key drivers of susceptibility. Finally, identified drug repurposing candidates present promising therapeutic avenues for further investigation.
Authors
- Andrius Baskys (ORCID: https://orcid.org/0000-0001-6280-5005)
- Ashley H. Duche
- Oliver Tan
- Rachita K. Sumbria (ORCID: https://orcid.org/0000-0002-7459-0723)
- Moom R. Roosan (ORCID: https://orcid.org/0000-0002-5318-5120)
Institutions
- Chapman University (US)
- University of California, Irvine (US)
- Western University of Health Sciences (US)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-10-02
- DOI
- https://doi.org/10.3389/fnagi.2025.1591946
- Citations
- 1
- Primary Topic
- Bioinformatics and Genomic Networks
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Chapman University
- National Institutes of Health