A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of QP002 for the Treatment of Post-Operative Pain After Tension-Free Repair of Open Unilateral Inguinal Hernia

QP002 demonstrated favorable safety profiles and exhibited distinct extended-release pharmacokinetic (PK) characteristics in single-ascending-dose administration. High doses of QP002 showed potential for postoperative incisional infiltration to control pain. Future studies will further explore its efficacy and safety in broader clinical applications.

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Publication Details

Journal
Drug Design Development and Therapy
Published
2025-10-01
DOI
https://doi.org/10.2147/dddt.s518200
Primary Topic
Anesthesia and Pain Management
Type
article
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article

A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of QP002 for the Treatment of Post-Operative Pain After Tension-Free Repair of Open Unilateral Inguinal Hernia

Shaoxing Liu, Xianjie Zhang, Lina Yang, Keyu Xie et al.
Drug Design Development and Therapy
Anesthesia and Pain Management
article

A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of QP002 for the Treatment of Post-Operative Pain After Tension-Free Repair of Open Unilateral Inguinal Hernia

Shaoxing Liu, Xianjie Zhang, Lina Yang, Keyu Xie, Dejun Cao, Mengchang Yang, Jinyu Liu
article en

Abstract

QP002 demonstrated favorable safety profiles and exhibited distinct extended-release pharmacokinetic (PK) characteristics in single-ascending-dose administration. High doses of QP002 showed potential for postoperative incisional infiltration to control pain. Future studies will further explore its efficacy and safety in broader clinical applications.

Drug Design Development and TherapyVol. Volume 19
University of Electronic Science and Technology of China (CN), Affiliated Hospital of Southwest Medical University (CN), Deyang Stomatological Hospital (CN), Chengdu Second People's Hospital (CN)
Openalex Percentile: Top 57%
Anesthesia and Pain Management
DOIOpen Access PDFOpenAlex
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A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of QP002 for the Treatment of Post-Operative Pain After Tension-Free Repair of Open Unilateral Inguinal Hernia — Shaoxing Liu, Xianjie Zhang, et al. · Drug Design Development and Therapy (2025) | TGRS Research Map | TGRS