Establishment of a value assessment framework for orphan drugs in China: an application of the discrete choice experiment in multicriteria decision analysis

Our study provides a new research perspective and methodological support for the value assessment of orphan drugs. When establishing a value assessment framework for orphan drugs in China, overall, the medical insurance access prioritized disease severity, and improvement in health-related quality of life. The application of discrete choice experiment proves to be a powerful tool for weighting criteria in healthcare multicriteria decision analysis framework and should be further explored for the value assessment of orphan drugs. Our findings offer a structured, evidence-based framework to support access and reimbursement decisions for orphan drugs.