Premature renal epithelial cell senescence promoted by LXN/Rps3/p53 signaling pathway activation increases calcium oxalate crystal deposition by altering macrophage polarization
Our results demonstrate that kidney macrophage phenotype changes are related, at least in part, to RTEC senescence, and a strategy to modulate the cellular senescence of RTECs is promising as a new target for immunotherapy to treat nephrolithiasis and other age-related diseases.
Authors
- Wanhai Xu (ORCID: https://orcid.org/0000-0003-3442-7988)
- Junmin Xue (ORCID: https://orcid.org/0000-0003-3349-1873)
- Guan-Hua Jing
- Maolin Chu (ORCID: https://orcid.org/0000-0002-6285-7777)
- Juan Zhang (ORCID: https://orcid.org/0000-0002-4974-4540)
- Wenjing Li (ORCID: https://orcid.org/0000-0002-4776-2016)
- Hongying Li (ORCID: https://orcid.org/0000-0002-1109-0799)
- Su Jiang (ORCID: https://orcid.org/0009-0006-1030-5096)
Institutions
- Harbin Medical University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- Henan Provincial People's Hospital (CN)
- Zhengzhou People's Hospital (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1658989
- Citations
- 1
- Primary Topic
- Biomedical Research and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 1.47