Optimizing HLA desensitization: serum dilution strategies and platform-specific MFI thresholds for antibody-mediated rejection risk in kidney transplantation
Serum dilution improves the clinical interpretation of DSA intensity and refines risk assessment in desensitized KT candidates. Our findings support the integration of platform-specific MFI cutoffs and dilution-based antibody profiling into organ acceptance strategies for highly sensitized patients.
Authors
- Rangolie Kaveri
- Fabienne Farce
- Dominique Bertrand
- Céline Dard (ORCID: https://orcid.org/0000-0002-5843-0842)
- Mathilde Lemoine (ORCID: https://orcid.org/0000-0001-5985-8042)
- Lionel Rostaing (ORCID: https://orcid.org/0000-0002-5130-7286)
- Thomas Jouve
- Johan Noble (ORCID: https://orcid.org/0000-0002-2329-0392)
- Charlotte Laurent (ORCID: https://orcid.org/0000-0002-8311-7970)
- Dominique Guerrot
- Paolo Malvezzi (ORCID: https://orcid.org/0000-0001-9359-2313)
Institutions
- Centre Hospitalier Universitaire de Grenoble (FR)
- Établissement Français du Sang (FR)
- Université de Rouen Normandie (FR)
- Université Grenoble Alpes (FR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1661977
- Citations
- 1
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.99