Visualizing early allograft rejection: an M1 macrophage-specific GLUT1 probe predicts TCMR onset in renal transplantation
M1-type macrophages are recruited in large numbers in the early stage of transplantation and play a key role in the progression of rejection. Glucose transporter-1 (GLUT1) is crucial for M1-type macrophages to exert pro-inflammatory effects. In the early stage of rejection, due to the high metabolic demand of M1-type macrophages, the expression of GLUT1 is significantly upregulated. These findings highlight the potential of GLUT1 as a predictive biomarker for guiding early and precise monitoring of rejection. In conclusion, this study provides an alternative method for early and non-invasive monitoring of allograft rejection.
Authors
- Fanchao Wei (ORCID: https://orcid.org/0009-0004-1603-2792)
- Changhong Shi (ORCID: https://orcid.org/0000-0001-6771-2481)
- Song Hong-tao (ORCID: https://orcid.org/0000-0002-0829-2680)
- Ruochen Qi (ORCID: https://orcid.org/0000-0001-9073-4996)
- Lang Li (ORCID: https://orcid.org/0000-0001-7154-891X)
- Shuaijun Ma
- Weijun Qin (ORCID: https://orcid.org/0000-0002-7509-7164)
- Dayuan Huang
- Jingliang Zhang
- Zhaoxiang Wang (ORCID: https://orcid.org/0000-0001-6577-0565)
- Zhengxuan Li (ORCID: https://orcid.org/0000-0001-9907-1543)
- Shichao Han (ORCID: https://orcid.org/0000-0001-5404-7347)
- Yuxuan Du (ORCID: https://orcid.org/0000-0002-1193-9756)
Institutions
- Air Force Engineering University (CN)
- Xijing Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1670370
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00