Bulk and single-cell transcriptome profiling reveals the dynamic immune response in granulomatous amebic encephalitis caused by Balamuthia mandrillaris: a cohort study
Overall, our study aimed to elucidate the pathogenic mechanisms underlying <i>B. mandrillaris</i> GAE, providing novel insights into the associated immune responses.
Authors
- Ying Ge (ORCID: https://orcid.org/0000-0001-6667-409X)
- Jingjia Zhang (ORCID: https://orcid.org/0000-0002-8285-950X)
- Huanwen Wu (ORCID: https://orcid.org/0000-0002-3996-3176)
- Xinmiao Jia (ORCID: https://orcid.org/0000-0002-6084-0146)
- Bin Yang (ORCID: https://orcid.org/0009-0002-9392-7392)
- Yingchun Xu (ORCID: https://orcid.org/0000-0003-4857-5201)
- Huifang Liu (ORCID: https://orcid.org/0000-0002-0214-0045)
- Jingjing Tian (ORCID: https://orcid.org/0000-0003-1396-0986)
- Wei Jiang (ORCID: https://orcid.org/0000-0003-0246-1890)
- Qiwen Yang (ORCID: https://orcid.org/0009-0006-0195-4342)
- Yang Cong
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Vision Medicals (China) (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1677014
- Primary Topic
- Legionella and Acanthamoeba research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Peking Union Medical College Hospital
- National Key Research and Development Program of China