A-080 Clinical Significance of Magnesium in Patients Undergoing Renal Dialysis

Abstract Background Magnesium (Mg+2) is the second most abundant intracellular cation in the human body, but only limited attention has been devoted to its value in patients suffering from Mg+2 disorders. The kidneys play an important role in the regulation of Mg+2 levels in the body. Due to the large amplitude of Mg+2 excretion by the kidneys, hypermagnesemia is common in renal failure. The aim of the present study was to explore Mg+2 disturbances and their correlation with major biochemical parameters and mortality in patients undergoing renal dialysis. Methods A total of 330 dialysis patients and 210 age-matched controls were included in this study. Clinicodemographic characteristics of participants were recorded carefully. Prior to dialysis, 10 mL of blood was collected and biochemical parameters including serum Mg+2, Na+, K+, Ca+2, P, FT3, FT4, TSH, PTH, urea, creatinine, iron, TIBC, hemoglobin, and ferritin were measured. Results Our results showed that serum Mg+2 levels were significantly higher in the dialysis patients than the control group (p <0.05). Mg+2 levels were also significantly higher in peritoneal dialysis patients than in hemodialysis patients (p <0.05). Additionally, we found that hypermagnesemia was more prevalent than hypomagnesaemia (31% and 19.5%, respectively). Serum FT4 was also significantly lower in dialysis patients than controls (p <0.05). Interestingly, our regression model indicates that diabetes is significantly associated with higher mortality in dialysis patients (p <0.05). Conclusion This study showed that dialysis patients had higher serum Mg+2 levels than normal individuals. In addition, there was no correlation between Mg+2 levels and mortality in dialysis patients. Because Mg+2 disturbances can affect the outcome of a dialysis patient in so many ways, we recommend regular monitoring of a patient*s Mg+2 levels.