Integration of network pharmacology, transcriptomics and single-cell sequencing to explore the effect of Rougan Keli in alleviating liver cirrhosis
Rgkl significantly attenuated hepatic injury and fibrosis. Mechanistically, Rgkl modulated LSEC lipid metabolism and phenotypic regulation, and suppressed HSC contraction and activation. Key active components contributing to these effects included Paeonilactone C, Levistilide A, and Quercetin.
Authors
- Chen Jin (ORCID: https://orcid.org/0000-0001-6068-2785)
- Li Wu (ORCID: https://orcid.org/0000-0001-9380-8620)
- Tianle Ma (ORCID: https://orcid.org/0000-0003-1533-3636)
- Huihua Fang
- Zhipeng Chen (ORCID: https://orcid.org/0000-0003-0418-5236)
- Yulan Wang (ORCID: https://orcid.org/0000-0002-2831-8737)
- Suzhou Huang (ORCID: https://orcid.org/0000-0002-7647-9375)
- Xin Ding (ORCID: https://orcid.org/0009-0002-8576-5776)
- Xinyu Wu (ORCID: https://orcid.org/0000-0002-9094-9951)
- Yiheng Zhang (ORCID: https://orcid.org/0000-0002-6245-3780)
- Tong Zhu
- Xujing Gu
Institutions
- Nanjing University of Chinese Medicine (CN)
- Soochow University (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1186/s13020-025-01220-z
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00