Effects of vitamin D supplementation on T cell activation and regulatory T cell development in <i>Ldlr</i><sup>−/−</sup> mice
The higher <i>Foxp3</i> expression and IL-10 production observed in the ATH suggest the activation of compensatory mechanisms to counteract inflammation. Enhanced TCR signaling in the ATH, likely associated with oxygen depletion due to heightened energy demand, may have contributed to the elevated <i>Hif1a</i> expression. The lower <i>Zap70</i> expression in the vDS suggests that vitamin D supplementation suppresses T cell activation.
Authors
- Ga Young Lee (ORCID: https://orcid.org/0000-0002-3906-0671)
- Sung Nim Han (ORCID: https://orcid.org/0000-0003-0647-2992)
- Hye-Won Shin
- Yin Ji Lu
- Soomin Yoo
- Yun-Jung Lee
- W Y Choi
- Dalli Nam
Institutions
- Seoul National University (KR)
- National Institute of Ecology (IN)
- National Institute of Ecology (KR)
Publication Details
- Journal
- Nutrition Research and Practice
- Published
- 2025-01-01
- DOI
- https://doi.org/10.4162/nrp.2025.19.5.698
- Citations
- 1
- Primary Topic
- Vitamin D Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- National Research Foundation
- Ministry of Science and ICT, South Korea