An IEDDA reaction of propargyl sulfonium salts and tetrazines: a versatile [4 + 2] modular assembly
Propargyl sulfonium salts serve as fast and mild electron-rich dienophiles in inverse-electron-demand [4 + 2] cycloadditions with tetrazines, enabling site-specific methionine labeling and macrocyclization in peptides.
Authors
- Wenteng Chen (ORCID: https://orcid.org/0000-0001-9366-3679)
- Huajian Zhu (ORCID: https://orcid.org/0000-0002-6786-8811)
- Jiaan Shao (ORCID: https://orcid.org/0000-0001-8735-3236)
- Zheng Wang (ORCID: https://orcid.org/0000-0002-7380-9404)
- Qi Zhu (ORCID: https://orcid.org/0000-0002-4325-0769)
- Jiankang Zhang (ORCID: https://orcid.org/0000-0003-0365-7238)
Institutions
- Hangzhou Normal University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Organic Chemistry Frontiers
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5qo01092f
- Primary Topic
- Catalytic Cross-Coupling Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00