Stratifying lung adenocarcinoma risk with multi-ancestry polygenic risk scores in East Asian never-smokers

Multi-ancestry PRS approaches enhance LUAD risk stratification in East Asian never-smokers, with consistent external validation, suggesting future clinical utility.

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Journal
JNCI Journal of the National Cancer Institute
Published
2025-09-18
DOI
https://doi.org/10.1093/jnci/djaf272
Primary Topic
Cancer-related molecular mechanisms research
Type
article
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article

Stratifying lung adenocarcinoma risk with multi-ancestry polygenic risk scores in East Asian never-smokers

Ann G. Schwartz, Shingo Matsumoto, Junjie Wu, Paul Brennan et al.
JNCI Journal of the National Cancer Institute
Cancer-related molecular mechanisms research
article

Stratifying lung adenocarcinoma risk with multi-ancestry polygenic risk scores in East Asian never-smokers

Ann G. Schwartz, Shingo Matsumoto, Junjie Wu, Paul Brennan, Hongbing Shen, Jacob Williams, Hongxia Ma, Adonina Tardón, Megumi Hara, Yukihide Momozawa, Sanjay Shete, I‐Shou Chang, Brian Richardson, Qiuyin Cai, Stephen Lam, Jiang Chang, Pan‐Chyr Yang, Wei Jie Seow, Angela Cox, Shilan Li, Kimihiro Shimizu, Jihua Li, Yataro Daigo, Guoping Wu, Angeline S. Andrew, Kenji Takeuchi, Ryuji Hamamoto, Melinda C. Aldrich, Bryan A. Bassig, Jiyeon Choi, Chong‐Jen Yu, Sook Whan Sung, Hong Dai, Yuichiro Nishida, Chao A. Hsiung, Lei Song, Adeline Seow, Baosen Zhou, Neil E. Caporaso, Kyong Hwa Park, Yeul Hong Kim, Akiteru Goto, Richard S. Houlston, Kenji Wakai, Alan Sihoe, Kouya Shiraishi, Z. Wang, Zhihua Yin, Takashi Kohno, Motoki Iwasaki, Batel Blechter, Demetrius Albanes, Angela Risch, Wu‐Chou Su, Christopher Ian Amos, Wei Wu, Susanne M. Arnold, Jcm Ho, Roel C.H. Vermeulen, Jin Eun Choi, Xifeng Wu, Yoichiro Kamatani, Mattias Johansson, Wen‐Chang Wang, John K. Field, Bao‐Liang Song, H. Dean Hosgood, Kuang Lin, Kōichi Goto, Juncheng Dai, Nathaniel Rothman, Tangchun Wu, Gong Yang, Nilanjan Chatterjee, Yoshinori Murakami, Katrina Wyatt, Chang Hyun Kang, Masahiro Tsuboi, Ivan Gorlov, Lambertus A.L.M. Kiemeney, Hsien-Chih Lin, Masashi Kobayashi, Taiki Yamaji, Shih Sheng Jiang, Jiucun Wang, Qing Lan, In Kyu Park, Rayjean J. Hung, Chin‐Fu Hsiao, Hsiao-Han Hung, Bu‐Tian Ji, Takayuki Honda, Peng Guan, Parichoy Pal Choudhury, Chen Chu, Li-Hsin Chien, Tongwu Zhang, Yasushi Yatabe, Yoshihiro Minamiya, Michael P.A. Davies, Keitaro Matsuo, Matthew B. Schabath, Belynda D. Hicks, Min‐Ho Shin, Hidehito Horinouchi, Mitchell J. Machiela, Heike Bickeböller, Iona C. Cheng, Norie Sawada, Koichi Matsuda, Kjell Grankvist, Gee-Chen Chang, Wen Tan, Xu‐Chao Zhang, Stig E. Bojesen, Yohei Miyagi, In‐Jae Oh, Olga Y. Gorlova, Yu‐Tang Gao, Yoichi Ohtaki, Philip Lazarus, Gad Rennert, Zhibin Hu, Laura Burdett, Victoria L. Stevens, Shan Zienolddiny-Narui, Amy Hutchinson, James McKay, Motonobu Saito, Chung‐Hsing Chen, Wei Hu, Charles E. Breeze, Jianjun Liu, Yuqing Li, Yang Yang, Yifan Wang, Wei Zheng, Jia Liu, Haoyu Zhang, Jin Hee Kim, Jie Liu, Ping Yang, Kexin Chen, Yi-Long Lung Cancer Wu, Geoffrey Liu, Xuelian Li, Dongxin Lin, Jae Yong Park, Meng Zhu, Junwen Wang, Hong Zheng, Victor Lee, Jun Xu, Fusheng Wei, Young Tae Kim, Hee Nam Kim, Kenichi Okubo, Yangwu Ren, Atsushi Takahashi, Young‐Chul Kim, Jian‐Min Yuan, Loı̈c Le Marchand, Sun-Seog Kweon, Hiroyuki Suzuki, Xiao Shu, Maria Pik Wong, Zhengming Chen, Sonja I Berndt, Stephen J Chanock, Hideo Kunitoh, Lap Ping Chung, John K. C. Chan, Jianxin Shi, Kuan‐Yu Chen, Kazumi Tanaka, Ann Chao, Robin G. Walters, T. Y. Qi, Joseph F. Fraumeni, Fiona Taylor, Hyo‐Sung Jeon, Fang-Yu Tsai, H. E. Wichmann, Yun Chul Hong, Tzu‐Yu Chen, Maria Teresa Landi, Junjie Zhu, Yi Young Choi, Shun-ichi Watanabe, Meredith Yeager, Xiaoyu Wang, Chih‐Yi Chen, Yuh-Min Chen, D.C. Christiani, Chien-Jen Chen ScD, Christiana Karsonaki, Jason Yy Wong Sm
article en

Abstract

Multi-ancestry PRS approaches enhance LUAD risk stratification in East Asian never-smokers, with consistent external validation, suggesting future clinical utility.

JNCI Journal of the National Cancer InstituteVol. 118(2)
Shenyang Medical College (CN), Chonnam National University (KR), University of North Carolina at Chapel Hill (US), Leidos (United States) (US), Inova Health System (US), University of Hawaiʻi at Mānoa (US), University of Copenhagen (DK), Tokyo Medical and Dental University (JP), American Cancer Society (US), BC Cancer Agency (CA), Albert Einstein College of Medicine (US), Fukushima Medical University (JP), St. Jude Children's Research Hospital (US), Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA), University of Hawaii System (US), National Institute of Occupational Health (NO), Massachusetts Department of Public Health (US), Shanghai Medical College of Fudan University (CN), The University of Texas MD Anderson Cancer Center (US), Harvard University (US), Shinshu University (JP), Seoul National University (KR), Institute of Cancer Research (GB), Johns Hopkins University (US), Radboud University Nijmegen (NL), University of Liverpool (GB), National Yang Ming Chiao Tung University (TW), Shiga University of Medical Science (JP), National Chung Hsing University (TW), Universidad de Oviedo (ES), National Health Research Institutes (TW), Gunma University (JP), National University of Singapore (SG), Cancer Research Institute (US), Tunghai University (TW), Zimmer Biomet (Netherlands) (NL), Technion – Israel Institute of Technology (IL), Saga University (JP), German Cancer Research Center (DE), University of California, San Francisco (US), Baylor College of Medicine (US), University of Salzburg (AT), Shanghai Jiao Tong University (CN), Georgetown University (US), Wayne State University (US), Utrecht University (NL), Korea University (KR), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Cotton (United States) (US), Akita University (JP), Lunenfeld-Tanenbaum Research Institute (CA), Heidelberg University (DE), University of Taipei (TW), Fudan University (CN), Johns Hopkins Medicine (US), Georgetown University Medical Center (US), Renji Hospital (CN), Queen Mary Hospital (CN), Castle Peak Hospital (CN), Gleneagles Hospital (SG), Markey Cancer Center (US), New Generation University College (ET), Tianjin Medical University Cancer Institute and Hospital (CN), Gentofte Hospital (DK), Princess Margaret Cancer Centre (CA), Seoul National University Hospital (KR), Radboud University Medical Center (NL), Taipei Veterans General Hospital (TW), Seoul National University Bundang Hospital (KR), University of California System (US), Sejong University (KR), Helmholtz Zentrum München (DE), Kanagawa Prefectural Hospital Organization (JP), Moffitt Cancer Center (US), Kyungpook National University (KR), National Dong Hwa University (TW), University of Oxford (GB), Genomics Research Center, Academia Sinica (TW), National Cancer Center (US), Fred Hutch Cancer Center (US), The Barbara Ann Karmanos Cancer Institute (US), Taichung Veterans General Hospital (TW), Chonnam National University Hospital (KR), Cancer Center of Hawaii (US), Kyungpook National University Medical Center (KR), Research Center for Applied Science, Academia Sinica (TW), Zimmer Biomet (Germany) (DE), Shandong Tumor Hospital (CN), Institute of Sociology, Academia Sinica (TW), Japanese Red Cross Medical Center (JP), Chung Shan Medical University Hospital (TW), Qujing Normal University (CN), World Health Organization (CH), National Heart, Lung, and Blood Institute (US), University of Tokyo Hospital (JP), China National Environmental Monitoring Center (CN), USC Norris Comprehensive Cancer Center (US), Nephrologisches Zentrum Goettingen (DE), Houston Institute for Clinical Research (US), Mayo Clinic in Arizona (US), Zhongshan Hospital (CN), Shanghai Pulmonary Hospital (CN), Jiangsu Cancer Hospital (CN), UPMC Hillman Cancer Center (US), Center for Global Health (US), German Center for Lung Research (DE), Frederick National Laboratory for Cancer Research (US), Sinai Health System (CA), National Taiwan University Hospital (TW), Laboratoire d’immunologie intégrative du cancer (FR), Aichi Cancer Center (JP), University of Pittsburgh Medical Center (US), First Hospital of China Medical University (CN), National Cancer Institute (US), New Mexico Cancer Center (US), Communication University of Zhejiang (CN), National Cancer Center Hospital East (JP), Guangdong Academy of Medical Sciences (CN), Cancer Genetics (United States) (US), Fukushima Medical University Hospital (JP), Chonnam National University Hwasun Hospital (KR), National University Health System (SG), Children's Cancer Center (US), RIKEN Center for Integrative Medical Sciences (JP), Xiamen Chang Gung Hospital (CN), National Hsinchu University of Education (TW), Tokyo National Hospital (JP), National Cheng Kung University Hospital (TW), Pharmaceutical Biotechnology (Czechia) (CZ), Korea University (JP), Liaoning Cancer Hospital & Institute (CN), Tokyo Medical and Dental University Hospital (JP), Shandong First Medical University (CN), Gunma University Hospital (JP), Queen Elizabeth Hospital (CN), Centre international de recherche sur le cancer (FR), Kanagawa Cancer Center, University of Hawaii Cancer Center, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research Inc. (United States), Taipei Medical University (TW), Huazhong University of Science and Technology (CN), National Cancer Research Institute (GB), Tianjin Medical University (CN), Nagoya University (JP), University at Buffalo, State University of New York (US), Genome Institute of Singapore (SG), Korea Research Institute of Bioscience and Biotechnology (KR), The University of Tokyo (JP), Zhejiang University (CN), Nippon Medical School (JP), Ludwig-Maximilians-Universität München (DE), Nanjing Medical University (CN), Academia Sinica (TW), University of Hong Kong (HK), Vanderbilt University Medical Center (US), Umeå University (SE), University of Sheffield (GB), Chung Shan Medical University (TW), China Medical University (CN)
Openalex Percentile: Top 66%
Cancer-related molecular mechanisms research
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