Stratifying lung adenocarcinoma risk with multi-ancestry polygenic risk scores in East Asian never-smokers
Multi-ancestry PRS approaches enhance LUAD risk stratification in East Asian never-smokers, with consistent external validation, suggesting future clinical utility.
Authors
- Ann G. Schwartz (ORCID: https://orcid.org/0000-0002-9525-1157)
- Shingo Matsumoto (ORCID: https://orcid.org/0000-0003-2698-0839)
- Junjie Wu (ORCID: https://orcid.org/0000-0002-4000-7026)
- Paul Brennan (ORCID: https://orcid.org/0000-0002-0518-8714)
- Hongbing Shen (ORCID: https://orcid.org/0000-0002-2581-5906)
- Jacob Williams (ORCID: https://orcid.org/0000-0001-8206-4128)
- Hongxia Ma (ORCID: https://orcid.org/0000-0002-2462-9693)
- Adonina Tardón (ORCID: https://orcid.org/0000-0001-5150-1209)
- Megumi Hara (ORCID: https://orcid.org/0000-0002-8708-3237)
- Yukihide Momozawa (ORCID: https://orcid.org/0000-0001-5638-3504)
- Sanjay Shete (ORCID: https://orcid.org/0000-0001-7622-376X)
- I‐Shou Chang (ORCID: https://orcid.org/0000-0002-6254-8114)
- Brian Richardson (ORCID: https://orcid.org/0000-0002-7332-9152)
- Qiuyin Cai (ORCID: https://orcid.org/0000-0002-9384-5648)
- Stephen Lam (ORCID: https://orcid.org/0000-0002-3964-1492)
- Jiang Chang (ORCID: https://orcid.org/0000-0001-8551-9458)
- Pan‐Chyr Yang (ORCID: https://orcid.org/0000-0001-6330-6048)
- Wei Jie Seow (ORCID: https://orcid.org/0000-0002-9114-854X)
- Angela Cox (ORCID: https://orcid.org/0000-0002-5138-1099)
- Shilan Li (ORCID: https://orcid.org/0000-0002-1132-1550)
- Kimihiro Shimizu (ORCID: https://orcid.org/0000-0003-4076-5174)
- Jihua Li (ORCID: https://orcid.org/0000-0001-8651-3840)
- Yataro Daigo (ORCID: https://orcid.org/0000-0002-0915-3025)
- Guoping Wu (ORCID: https://orcid.org/0000-0002-6002-8625)
- Angeline S. Andrew (ORCID: https://orcid.org/0000-0002-3731-5300)
- Kenji Takeuchi (ORCID: https://orcid.org/0000-0001-8769-8955)
- Ryuji Hamamoto (ORCID: https://orcid.org/0000-0002-2632-1334)
- Melinda C. Aldrich (ORCID: https://orcid.org/0000-0003-3833-8448)
- Bryan A. Bassig (ORCID: https://orcid.org/0000-0002-0278-8597)
- Jiyeon Choi (ORCID: https://orcid.org/0000-0002-0955-2384)
- Chong‐Jen Yu (ORCID: https://orcid.org/0000-0001-5664-9392)
- Sook Whan Sung (ORCID: https://orcid.org/0000-0002-8480-0915)
- Hong Dai (ORCID: https://orcid.org/0000-0002-3009-5536)
- Yuichiro Nishida (ORCID: https://orcid.org/0000-0003-2320-7234)
- Chao A. Hsiung (ORCID: https://orcid.org/0000-0003-1427-6641)
- Lei Song (ORCID: https://orcid.org/0000-0002-9287-9643)
- Adeline Seow (ORCID: https://orcid.org/0000-0001-5434-7673)
- Baosen Zhou (ORCID: https://orcid.org/0000-0002-5311-3880)
- Neil E. Caporaso (ORCID: https://orcid.org/0000-0001-7562-4609)
- Kyong Hwa Park (ORCID: https://orcid.org/0000-0002-2464-7920)
- Yeul Hong Kim (ORCID: https://orcid.org/0000-0002-2555-2333)
- Akiteru Goto (ORCID: https://orcid.org/0000-0001-8776-9004)
- Richard S. Houlston (ORCID: https://orcid.org/0000-0002-5268-0242)
- Kenji Wakai (ORCID: https://orcid.org/0000-0001-7388-7157)
- Alan Sihoe (ORCID: https://orcid.org/0000-0003-3891-6180)
- Kouya Shiraishi (ORCID: https://orcid.org/0000-0002-5821-7400)
- Z. Wang
- Zhihua Yin (ORCID: https://orcid.org/0000-0003-0850-680X)
- Takashi Kohno (ORCID: https://orcid.org/0000-0002-5371-706X)
- Motoki Iwasaki (ORCID: https://orcid.org/0000-0003-3319-4131)
- Batel Blechter (ORCID: https://orcid.org/0000-0001-7610-2554)
- Demetrius Albanes (ORCID: https://orcid.org/0000-0001-8330-4293)
- Angela Risch (ORCID: https://orcid.org/0000-0002-8026-5505)
- Wu‐Chou Su (ORCID: https://orcid.org/0000-0003-2953-4105)
- Christopher Ian Amos (ORCID: https://orcid.org/0000-0002-8540-7023)
- Wei Wu (ORCID: https://orcid.org/0000-0002-4894-7178)
- Susanne M. Arnold (ORCID: https://orcid.org/0000-0001-6542-9551)
- Jcm Ho (ORCID: https://orcid.org/0000-0003-4499-5284)
- Roel C.H. Vermeulen (ORCID: https://orcid.org/0000-0003-4082-8163)
- Jin Eun Choi (ORCID: https://orcid.org/0000-0001-7833-2257)
- Xifeng Wu (ORCID: https://orcid.org/0000-0003-2980-8129)
- Yoichiro Kamatani (ORCID: https://orcid.org/0000-0001-8748-5597)
- Mattias Johansson (ORCID: https://orcid.org/0000-0002-3116-5081)
- Wen‐Chang Wang (ORCID: https://orcid.org/0000-0003-3124-2136)
- John K. Field (ORCID: https://orcid.org/0000-0003-3951-6365)
- Bao‐Liang Song (ORCID: https://orcid.org/0000-0002-6397-5935)
- H. Dean Hosgood (ORCID: https://orcid.org/0000-0003-4151-1133)
- Kuang Lin (ORCID: https://orcid.org/0000-0002-7360-3385)
- Kōichi Goto (ORCID: https://orcid.org/0000-0002-3023-2510)
- Juncheng Dai (ORCID: https://orcid.org/0000-0002-3909-5671)
- Nathaniel Rothman (ORCID: https://orcid.org/0000-0002-0866-9943)
- Tangchun Wu (ORCID: https://orcid.org/0000-0001-9931-5106)
- Gong Yang
- Nilanjan Chatterjee (ORCID: https://orcid.org/0000-0002-4175-5405)
- Yoshinori Murakami (ORCID: https://orcid.org/0000-0002-8098-6265)
- Katrina Wyatt (ORCID: https://orcid.org/0000-0001-7099-159X)
- Chang Hyun Kang (ORCID: https://orcid.org/0000-0002-1612-1937)
- Masahiro Tsuboi (ORCID: https://orcid.org/0000-0003-3031-5807)
- Ivan Gorlov (ORCID: https://orcid.org/0000-0001-8415-5656)
- Lambertus A.L.M. Kiemeney (ORCID: https://orcid.org/0000-0002-2368-1326)
- Hsien-Chih Lin
- Masashi Kobayashi (ORCID: https://orcid.org/0000-0001-5401-9581)
- Taiki Yamaji (ORCID: https://orcid.org/0000-0002-4799-8782)
- Shih Sheng Jiang (ORCID: https://orcid.org/0000-0003-1909-437X)
- Jiucun Wang (ORCID: https://orcid.org/0000-0003-2765-0620)
- Qing Lan
- In Kyu Park (ORCID: https://orcid.org/0000-0003-3550-5554)
- Rayjean J. Hung (ORCID: https://orcid.org/0000-0002-4486-7496)
- Chin‐Fu Hsiao (ORCID: https://orcid.org/0000-0003-1284-7260)
- Hsiao-Han Hung (ORCID: https://orcid.org/0000-0002-5466-4828)
- Bu‐Tian Ji (ORCID: https://orcid.org/0000-0002-8000-4997)
- Takayuki Honda (ORCID: https://orcid.org/0000-0002-1628-0698)
- Peng Guan (ORCID: https://orcid.org/0000-0003-0190-7301)
- Parichoy Pal Choudhury (ORCID: https://orcid.org/0000-0002-0857-0230)
- Chen Chu (ORCID: https://orcid.org/0000-0001-8084-0867)
- Li-Hsin Chien
- Tongwu Zhang (ORCID: https://orcid.org/0000-0003-2124-2706)
- Yasushi Yatabe (ORCID: https://orcid.org/0000-0003-1788-559X)
- Yoshihiro Minamiya
- Michael P.A. Davies (ORCID: https://orcid.org/0000-0002-7609-4977)
- Keitaro Matsuo (ORCID: https://orcid.org/0000-0003-1761-6314)
- Matthew B. Schabath (ORCID: https://orcid.org/0000-0003-3241-3216)
- Belynda D. Hicks (ORCID: https://orcid.org/0000-0001-8014-4888)
- Min‐Ho Shin (ORCID: https://orcid.org/0000-0002-2217-5624)
- Hidehito Horinouchi (ORCID: https://orcid.org/0000-0001-9090-801X)
- Mitchell J. Machiela (ORCID: https://orcid.org/0000-0001-6538-9705)
- Heike Bickeböller (ORCID: https://orcid.org/0000-0002-3361-5488)
- Iona C. Cheng (ORCID: https://orcid.org/0000-0003-4132-2893)
- Norie Sawada (ORCID: https://orcid.org/0000-0002-9936-1476)
- Koichi Matsuda (ORCID: https://orcid.org/0000-0001-7292-2686)
- Kjell Grankvist (ORCID: https://orcid.org/0000-0003-4289-2097)
- Gee-Chen Chang
- Wen Tan (ORCID: https://orcid.org/0000-0002-7231-7838)
- Xu‐Chao Zhang (ORCID: https://orcid.org/0000-0002-4138-8115)
- Stig E. Bojesen (ORCID: https://orcid.org/0000-0002-4061-4133)
- Yohei Miyagi (ORCID: https://orcid.org/0000-0002-0056-7010)
- In‐Jae Oh (ORCID: https://orcid.org/0000-0003-4837-1321)
- Olga Y. Gorlova (ORCID: https://orcid.org/0000-0001-8241-6322)
- Yu‐Tang Gao (ORCID: https://orcid.org/0000-0003-3904-1777)
- Yoichi Ohtaki (ORCID: https://orcid.org/0000-0001-5485-3234)
- Philip Lazarus (ORCID: https://orcid.org/0000-0002-8686-0874)
- Gad Rennert (ORCID: https://orcid.org/0000-0002-8512-068X)
- Zhibin Hu (ORCID: https://orcid.org/0000-0002-8277-5234)
- Laura Burdett
- Victoria L. Stevens (ORCID: https://orcid.org/0000-0003-0259-4407)
- Shan Zienolddiny-Narui
- Amy Hutchinson (ORCID: https://orcid.org/0000-0002-4962-2711)
- James McKay (ORCID: https://orcid.org/0000-0002-1787-3874)
- Motonobu Saito (ORCID: https://orcid.org/0000-0001-5072-3520)
- Chung‐Hsing Chen (ORCID: https://orcid.org/0000-0002-1205-7368)
- Wei Hu (ORCID: https://orcid.org/0000-0002-4826-4633)
- Charles E. Breeze (ORCID: https://orcid.org/0000-0002-5294-915X)
- Jianjun Liu (ORCID: https://orcid.org/0000-0002-3255-3019)
- Yuqing Li (ORCID: https://orcid.org/0000-0003-4929-126X)
- Yang Yang (ORCID: https://orcid.org/0000-0002-1290-6665)
- Yifan Wang (ORCID: https://orcid.org/0000-0001-7387-0654)
- Wei Zheng (ORCID: https://orcid.org/0000-0003-1226-070X)
- Jia Liu (ORCID: https://orcid.org/0000-0003-3614-9459)
- Haoyu Zhang (ORCID: https://orcid.org/0000-0001-6423-0444)
- Jin Hee Kim (ORCID: https://orcid.org/0000-0003-1204-7079)
- Jie Liu (ORCID: https://orcid.org/0000-0002-4966-1753)
- Ping Yang (ORCID: https://orcid.org/0000-0003-4074-2423)
- Kexin Chen (ORCID: https://orcid.org/0000-0003-4248-7681)
- Yi-Long Lung Cancer Wu (ORCID: https://orcid.org/0000-0002-3611-0258)
- Geoffrey Liu (ORCID: https://orcid.org/0000-0002-2603-7296)
- Xuelian Li (ORCID: https://orcid.org/0000-0002-2432-104X)
- Dongxin Lin (ORCID: https://orcid.org/0000-0002-8723-8868)
- Jae Yong Park (ORCID: https://orcid.org/0000-0001-7993-4495)
- Meng Zhu (ORCID: https://orcid.org/0000-0001-5122-1733)
- Junwen Wang (ORCID: https://orcid.org/0000-0002-4432-4707)
- Hong Zheng (ORCID: https://orcid.org/0000-0003-3725-4541)
- Victor Lee (ORCID: https://orcid.org/0000-0002-6283-978X)
- Jun Xu (ORCID: https://orcid.org/0000-0003-3507-0159)
- Fusheng Wei
- Young Tae Kim (ORCID: https://orcid.org/0000-0003-1738-6862)
- Hee Nam Kim (ORCID: https://orcid.org/0000-0002-6153-2612)
- Kenichi Okubo (ORCID: https://orcid.org/0000-0003-1092-7814)
- Yangwu Ren (ORCID: https://orcid.org/0009-0002-8100-577X)
- Atsushi Takahashi (ORCID: https://orcid.org/0000-0001-7099-8767)
- Young‐Chul Kim (ORCID: https://orcid.org/0000-0001-7019-7687)
- Jian‐Min Yuan (ORCID: https://orcid.org/0000-0002-7664-7084)
- Loı̈c Le Marchand (ORCID: https://orcid.org/0000-0001-5013-980X)
- Sun-Seog Kweon
- Hiroyuki Suzuki (ORCID: https://orcid.org/0000-0003-2383-5038)
- Xiao Shu (ORCID: https://orcid.org/0000-0002-5388-5282)
- Maria Pik Wong (ORCID: https://orcid.org/0009-0000-2337-6244)
- Zhengming Chen
- Sonja I Berndt
- Stephen J Chanock
- Hideo Kunitoh
- Lap Ping Chung
- John K. C. Chan
- Jianxin Shi
- Kuan‐Yu Chen
- Kazumi Tanaka (ORCID: https://orcid.org/0000-0002-7095-2248)
- Ann Chao
- Robin G. Walters
- T. Y. Qi
- Joseph F. Fraumeni
- Fiona Taylor
- Hyo‐Sung Jeon
- Fang-Yu Tsai
- H. E. Wichmann
- Yun Chul Hong (ORCID: https://orcid.org/0000-0003-4618-4215)
- Tzu‐Yu Chen
- Maria Teresa Landi (ORCID: https://orcid.org/0000-0003-4507-329X)
- Junjie Zhu (ORCID: https://orcid.org/0009-0000-8725-7375)
- Yi Young Choi
- Shun-ichi Watanabe
- Meredith Yeager
- Xiaoyu Wang (ORCID: https://orcid.org/0000-0002-7826-9785)
- Chih‐Yi Chen (ORCID: https://orcid.org/0000-0001-9285-1109)
- Yuh-Min Chen
- D.C. Christiani
- Chien-Jen Chen ScD
- Christiana Karsonaki
- Jason Yy Wong Sm
Institutions
- Shenyang Medical College (CN)
- Chonnam National University (KR)
- University of North Carolina at Chapel Hill (US)
- Leidos (United States) (US)
- Inova Health System (US)
- University of Hawaiʻi at Mānoa (US)
- University of Copenhagen (DK)
- Tokyo Medical and Dental University (JP)
- American Cancer Society (US)
- BC Cancer Agency (CA)
- Albert Einstein College of Medicine (US)
- Fukushima Medical University (JP)
- St. Jude Children's Research Hospital (US)
- Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
- University of Hawaii System (US)
- National Institute of Occupational Health (NO)
- Massachusetts Department of Public Health (US)
- Shanghai Medical College of Fudan University (CN)
- The University of Texas MD Anderson Cancer Center (US)
- Harvard University (US)
- Shinshu University (JP)
- Seoul National University (KR)
- Institute of Cancer Research (GB)
- Johns Hopkins University (US)
- Radboud University Nijmegen (NL)
- University of Liverpool (GB)
- National Yang Ming Chiao Tung University (TW)
- Shiga University of Medical Science (JP)
- National Chung Hsing University (TW)
- Universidad de Oviedo (ES)
- National Health Research Institutes (TW)
- Gunma University (JP)
- National University of Singapore (SG)
- Cancer Research Institute (US)
- Tunghai University (TW)
- Zimmer Biomet (Netherlands) (NL)
- Technion – Israel Institute of Technology (IL)
- Saga University (JP)
- German Cancer Research Center (DE)
- University of California, San Francisco (US)
- Baylor College of Medicine (US)
- University of Salzburg (AT)
- Shanghai Jiao Tong University (CN)
- Georgetown University (US)
- Wayne State University (US)
- Utrecht University (NL)
- Korea University (KR)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Cotton (United States) (US)
- Akita University (JP)
- Lunenfeld-Tanenbaum Research Institute (CA)
- Heidelberg University (DE)
- University of Taipei (TW)
- Fudan University (CN)
- Johns Hopkins Medicine (US)
- Georgetown University Medical Center (US)
- Renji Hospital (CN)
- Queen Mary Hospital (CN)
- Castle Peak Hospital (CN)
- Gleneagles Hospital (SG)
- Markey Cancer Center (US)
- New Generation University College (ET)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Gentofte Hospital (DK)
- Princess Margaret Cancer Centre (CA)
- Seoul National University Hospital (KR)
- Radboud University Medical Center (NL)
- Taipei Veterans General Hospital (TW)
- Seoul National University Bundang Hospital (KR)
- University of California System (US)
- Sejong University (KR)
- Helmholtz Zentrum München (DE)
- Kanagawa Prefectural Hospital Organization (JP)
- Moffitt Cancer Center (US)
- Kyungpook National University (KR)
- National Dong Hwa University (TW)
- University of Oxford (GB)
- Genomics Research Center, Academia Sinica (TW)
- National Cancer Center (US)
- Fred Hutch Cancer Center (US)
- The Barbara Ann Karmanos Cancer Institute (US)
- Taichung Veterans General Hospital (TW)
- Chonnam National University Hospital (KR)
- Cancer Center of Hawaii (US)
- Kyungpook National University Medical Center (KR)
- Research Center for Applied Science, Academia Sinica (TW)
- Zimmer Biomet (Germany) (DE)
- Shandong Tumor Hospital (CN)
- Institute of Sociology, Academia Sinica (TW)
- Japanese Red Cross Medical Center (JP)
- Chung Shan Medical University Hospital (TW)
- Qujing Normal University (CN)
- World Health Organization (CH)
- National Heart, Lung, and Blood Institute (US)
- University of Tokyo Hospital (JP)
- China National Environmental Monitoring Center (CN)
- USC Norris Comprehensive Cancer Center (US)
- Nephrologisches Zentrum Goettingen (DE)
- Houston Institute for Clinical Research (US)
- Mayo Clinic in Arizona (US)
- Zhongshan Hospital (CN)
- Shanghai Pulmonary Hospital (CN)
- Jiangsu Cancer Hospital (CN)
- UPMC Hillman Cancer Center (US)
- Center for Global Health (US)
- German Center for Lung Research (DE)
- Frederick National Laboratory for Cancer Research (US)
- Sinai Health System (CA)
- National Taiwan University Hospital (TW)
- Laboratoire d’immunologie intégrative du cancer (FR)
- Aichi Cancer Center (JP)
- University of Pittsburgh Medical Center (US)
- First Hospital of China Medical University (CN)
- National Cancer Institute (US)
- New Mexico Cancer Center (US)
- Communication University of Zhejiang (CN)
- National Cancer Center Hospital East (JP)
- Guangdong Academy of Medical Sciences (CN)
- Cancer Genetics (United States) (US)
- Fukushima Medical University Hospital (JP)
- Chonnam National University Hwasun Hospital (KR)
- National University Health System (SG)
- Children's Cancer Center (US)
- RIKEN Center for Integrative Medical Sciences (JP)
- Xiamen Chang Gung Hospital (CN)
- National Hsinchu University of Education (TW)
- Tokyo National Hospital (JP)
- National Cheng Kung University Hospital (TW)
- Pharmaceutical Biotechnology (Czechia) (CZ)
- Korea University (JP)
- Liaoning Cancer Hospital & Institute (CN)
- Tokyo Medical and Dental University Hospital (JP)
- Shandong First Medical University (CN)
- Gunma University Hospital (JP)
- Queen Elizabeth Hospital (CN)
- Centre international de recherche sur le cancer (FR)
- Kanagawa Cancer Center
- University of Hawaii Cancer Center
- Division of Cancer Epidemiology and Genetics
- Leidos Biomedical Research Inc. (United States)
- Taipei Medical University (TW)
- Huazhong University of Science and Technology (CN)
- National Cancer Research Institute (GB)
- Tianjin Medical University (CN)
- Nagoya University (JP)
- University at Buffalo, State University of New York (US)
- Genome Institute of Singapore (SG)
- Korea Research Institute of Bioscience and Biotechnology (KR)
- The University of Tokyo (JP)
- Zhejiang University (CN)
- Nippon Medical School (JP)
- Ludwig-Maximilians-Universität München (DE)
- Nanjing Medical University (CN)
- Academia Sinica (TW)
- University of Hong Kong (HK)
- Vanderbilt University Medical Center (US)
- Umeå University (SE)
- University of Sheffield (GB)
- Chung Shan Medical University (TW)
- China Medical University (CN)
Publication Details
- Journal
- JNCI Journal of the National Cancer Institute
- Published
- 2025-09-18
- DOI
- https://doi.org/10.1093/jnci/djaf272
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00