The Effect of Intensive Combined Exercise on the Lipid Profile and Hepatic Enzymes in Modeling Diet-Induced NAFLD Rats

Nonalcoholic fatty liver disease (NAFLD) refers to a comprehensive range of conditions, encompassing simple steatosis to advancing nonalcoholic steatohepatitis (NASH), hepatic fibrosis, and cirrhosis. While both aerobic exercise and resistance training (RT) have been shown to provide advantages for patients with NAFLD, there is still a need to investigate and delve into the potential effectiveness of exercise mode. The purpose of this study is to investigate the effect of exercise mode in NAFLD-induced rats. Twenty-one male Wistar rats were divided into three groups: 1) normal control, 2) NAFLD, and 3) NAFLD+combined training (CT). The intervention groups received HFFD for 15 weeks to induce NAFLD. After determination of NAFLD, CT was done for 8 weeks. Aspartate transaminase (AST) and triglyceride (TG) were significantly reduced in the NAFLD+CT compare to NAFLD.While there was no significant difference in the Low-density lipoprotein (LDL), AST, and alkaline phosphatase (ALP) in the NAFLD+CT. CT can lead to a reduction in liver fat content, improved liver function, and lowered levels of TG and cholesterol that causes improvement of NAFLD. Therefore, they can be used to reduce the complications of NAFLD. Although more studies are needed to confirm the results.