Characterization of myocardial microstructure for healthy female and male cohorts using cardiac diffusion tensor imaging with an ultra-high-performance gradient magnetic resonance imaging scanner
This is the first and largest single-center study to investigate cDTI in a large cohort (N>100) of healthy subjects performed with an ultra-high-performance gradient MR system. No significant difference was discovered in MD, FA, and HAT between men and women, suggesting biological sex does not impact myocardial microstructure in healthy subjects. Future work using ultra-high-performance systems should focus on the evaluation of microstructural changes in patients with cardiovascular disease.
Authors
- T. Garret
- Christopher Nguyen (ORCID: https://orcid.org/0000-0003-1475-2329)
- Danielle Kara (ORCID: https://orcid.org/0000-0001-8369-798X)
- Wen Tang (ORCID: https://orcid.org/0000-0002-2015-7625)
- Robert A. Eder (ORCID: https://orcid.org/0000-0003-0161-7937)
- Deborah Kwon (ORCID: https://orcid.org/0000-0003-2191-4111)
- Jaume Coll‐Font (ORCID: https://orcid.org/0000-0001-9341-6838)
- Oussama M. Wazni (ORCID: https://orcid.org/0000-0001-7115-7716)
- Anna N. Foster (ORCID: https://orcid.org/0000-0002-1838-7237)
- Animesh Tandon (ORCID: https://orcid.org/0000-0001-9769-8801)
- Salva R. Yurista (ORCID: https://orcid.org/0000-0001-9126-739X)
- Shi Chen (ORCID: https://orcid.org/0000-0003-1719-0536)
Institutions
- Cleveland Clinic (US)
- Cleveland Clinic Lerner College of Medicine (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Journal of Cardiovascular Magnetic Resonance
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jocmr.2025.101966
- Citations
- 1
- Primary Topic
- Cardiac Imaging and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 1.36