Correlation between TTF-1 expression and EGFR mutations in moroccan lung adenocarcinoma: A prospective six-year study
This study demonstrates a strong correlation between TTF-1 expression and common EGFR mutations, especially exon 19 deletions, in Moroccan patients with advanced lung adenocarcinoma. The association was most evident in never-smokers, supporting the role of TTF-1 and EGFR as complementary biomarkers in guiding diagnosis and treatment. Larger multicenter studies are warranted to further explore their prognostic value.
Authors
- Laila Bouguenouch (ORCID: https://orcid.org/0000-0002-4082-5432)
- Hinde El Fatemi (ORCID: https://orcid.org/0000-0002-0929-3167)
- Ismail Mouhrach (ORCID: https://orcid.org/0000-0002-3107-8906)
- Y. Ouadnouni
- Nawfel Mellas (ORCID: https://orcid.org/0000-0002-0987-3751)
- M. Serraj (ORCID: https://orcid.org/0000-0002-0750-3669)
- Fatima El Agy (ORCID: https://orcid.org/0000-0002-4467-4555)
- M. Smahi (ORCID: https://orcid.org/0000-0002-0830-1356)
- Badreeddine Alami (ORCID: https://orcid.org/0000-0002-8014-683X)
- Zineb Benbrahim
- Sara Boukansa (ORCID: https://orcid.org/0000-0003-4297-3380)
- B. Amara
- Mokhtar El Mekhtoume
Institutions
- Sidi Mohamed Ben Abdellah University (MA)
Publication Details
- Journal
- Cancer Treatment and Research Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.ctarc.2025.101012
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00