YBX1 Enhances the Stability of TM4SF1 in an m5C-Dependent Manner to Promote Bladder Cancer Proliferation and Glycolysis

YBX1 stabilizes TM4SF1 mRNA via m5C modification in BCa, activating β- catenin/c-Myc signaling to drive tumor growth and glycolysis. This reveals a novel therapeutic target for BCa.

Authors

Hongmei Luo (ORCID: https://orcid.org/0000-0001-8130-8565)
Hong Li (ORCID: https://orcid.org/0000-0002-3874-4860)
Yi Wang (ORCID: https://orcid.org/0000-0002-4954-6317)
Jian Tang
Liang Yu (ORCID: https://orcid.org/0009-0007-3922-3454)

Institutions

Jiangxi Pingxiang People's Hospital (CN)
University of South China (CN)

Publication Details

Journal: Combinatorial Chemistry & High Throughput Screening
Published: 2025-09-26
DOI: https://doi.org/10.2174/0113862073392269250825105059
Primary Topic: RNA modifications and cancer
Type: article
Field-Weighted Citation Impact: 0.00

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article

YBX1 Enhances the Stability of TM4SF1 in an m5C-Dependent Manner to Promote Bladder Cancer Proliferation and Glycolysis

Hongmei Luo, Hong Li, Yi Wang, Jian Tang et al.

Sep 26, 2025

Combinatorial Chemistry & High Throughput Screening

RNA modifications and cancer

article

YBX1 Enhances the Stability of TM4SF1 in an m5C-Dependent Manner to Promote Bladder Cancer Proliferation and Glycolysis

Hongmei Luo, Hong Li, Yi Wang, Jian Tang, Liang Yu

September 26, 2025article en

Abstract

YBX1 stabilizes TM4SF1 mRNA via m5C modification in BCa, activating β- catenin/c-Myc signaling to drive tumor growth and glycolysis. This reveals a novel therapeutic target for BCa.

Combinatorial Chemistry & High Throughput ScreeningVol. 28

Jiangxi Pingxiang People's Hospital (CN), University of South China (CN)

Openalex Percentile: Top 76%

RNA modifications and cancer

DOI Source OpenAlex

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YBX1 Enhances the Stability of TM4SF1 in an m5C-Dependent Manner to Promote Bladder Cancer Proliferation and Glycolysis — Hongmei Luo, Hong Li, et al. · Combinatorial Chemistry & High Throughput Screening (2025) | TGRS Research Map | TGRS