Amygdalin regulated vasoactive intestinal peptide receptor to protect alveolar epithelial barrier against lung injury induced by influenza a virus
Amygdalin is the key bioactive component of bitter apricot kernel, which exhibits protective effects in an IAV-induced pneumonia mouse model by activating the cAMP/PKA/p-PKA signaling cascade and recapitulating the biological effects of vasoactive intestinal peptide (VIP).
Authors
- Xiaohui Song (ORCID: https://orcid.org/0000-0002-3487-756X)
- Daofeng Chen (ORCID: https://orcid.org/0000-0003-3806-3114)
- Xunlong Shi (ORCID: https://orcid.org/0000-0002-7009-5629)
- Yan Lu (ORCID: https://orcid.org/0000-0002-9420-7090)
- Haiyan Zhu (ORCID: https://orcid.org/0000-0002-8109-6678)
- Ting Wang (ORCID: https://orcid.org/0000-0003-3172-1620)
- Miao Ye (ORCID: https://orcid.org/0009-0003-9211-352X)
Institutions
- Fudan University (CN)
- Pudong Medical Center (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1186/s13020-025-01221-y
- Citations
- 2
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 2.64