Zuojinwan Antagonizes Drug Resistance Transmission of Gastric CancerInduced by Hypoxia Through Exosomal Mir-30a Mediated Hedgehog/PD-L1 Signalling
These results indicate that hypoxia-induced exosomal miR-30a, derived from GCresistant drug cells, may promote chemoresistance in gastric cancer cells by activating Hedgehog- mediated PD-L1 signaling and can be attenuated by the involvement of ZJW.
Authors
- Hua Sui (ORCID: https://orcid.org/0000-0001-7255-4254)
- Zhenzhen Wei (ORCID: https://orcid.org/0000-0001-8676-9678)
- B. Li
- Zan Li (ORCID: https://orcid.org/0000-0002-9478-6918)
- Yuli Zhang (ORCID: https://orcid.org/0009-0009-3685-8360)
- Qingfeng Tang (ORCID: https://orcid.org/0000-0003-0309-4797)
- Zhen Chen (ORCID: https://orcid.org/0000-0001-8875-6926)
Institutions
- Henan University of Traditional Chinese Medicine (CN)
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
- Jiading District Central Hospital (CN)
- Zhengzhou City Hospital (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
- Henan Cancer Hospital (CN)
- First Affiliated Hospital of Henan University (CN)
Publication Details
- Journal
- Combinatorial Chemistry & High Throughput Screening
- Published
- 2025-09-29
- DOI
- https://doi.org/10.2174/0113862073367894250925093658
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94