APPLICATION OF "SMART MATERIALS" IN SAMPLE PREPARATION OF BIOLOGICAL FLUIDS AND ENVIRONMENTAL OBJECTS

Sample preparation of natural objects requires the development of highly sensitive and selective methods for extracting and concentrating biologically active substances. So-called smart materials, which are selected to solve specific analytical problems, are promising in this area. The review considers the main types of such materials (ionic liquids, eutectic solvents, nanomaterials, organometallic and covalent framework structures, molecularly imprinted polymers), their specific features and specific examples of application in chemical analysis for 2020–2025. The possibilities of using smart materials in the analysis of biological fluids and natural objects, available microextraction approaches and methods for subsequent determination are considered. The achieved advantages over previously proposed approaches are emphasized.