Modern approaches to the comprehensive assessment of the human immune status under radiation exposure. Review (part 2)

The importance of an integrated approach to assessing the human immune status based on studying immunity indices in dynamics after radiation exposure is dictated not only by the need to form risk groups among irradiated individuals, but also by the special significance of studying the role of immune disorders in the pathogenesis of late effects of irradiation. However, in environmental immunology, in particular, when assessing the impact of ionizing radiation on the human body, such an analysis is extremely difficult, often impossible. In recent years, the features of the human immune status have been studied in combination with established or potential molecular genetic markers of hereditary predisposition to various pathological conditions with multifactorial etiology. The presented part of the analytical review contains modern scientific information on methodological approaches to the integrated assessment of the human immune status based on a comprehensive analysis of immunity indices, metabolic and hormonal status, as well as other mathematical and statistical methods and mathematical modeling of processes occurring in the immune system. Each approach is based on its own methodological framework, which is rapidly improving, but in practical application has both advantages and limitations.v