SERUM SELENIUM STATUS AND THYROID FUNCTION

Aim: The preliminary study is undertaken to evaluate the selenium status, glutathione (G.SH) levels and glutathione peroxidase activity (GPx) in hypothyroid patients. Materials And Methods; Among 200 cases a total of 62 study subjects, with hypothyroidism referred to one of the cardiology institute were taken for the present study. The serum fasting blood glucose (FBG), lipid profile,T3,T4 and Thyroid stimulating hormone (TSH) were measured by automated methods using electro chemiluminescence. Selenium was measured by using Graphite furnace Atomic absorption spectrophotometer, Shimadzu. GPx was determined by Enzyme linked immunoassay. Results And Discussion: There was a significant decrease in serum selenium levels in hypothyroid cases compared to the control subjects accompanied by a decrease in GPx activity in hypothyroid patients.G.SH levels did not show marked change in hypothyroid cases compared to control subjects.The levels of total cholesterol and LDL cholesterol were increased in hypothyroid cases with a non-significant increase in HDL cholesterol. Selenium dependent enzyme glutathione peroxidase shows a positive correlation between selenium status in hypothyroid patients.