CRYOPROTECTANT BASED ON A GLASS-FORMING AQUEOUS SOLUTION OF MAGNESIUM ACETATE

For the first time a cryoprotectant based on glass-forming aqueous solution of magnesium acetate, a metal vital for the human body, was obtained and studied by DSC method. This cryoprotectant - Mg(CHCOO) ∙ 12HO - surpasses the available analogues by the following parameters: it has a high glass-forming ability (it passes from the glassy state to the liquid state without crystallization), is non-toxic and easy to obtain. Its cryoprotective ability, proved on chicken egg white, does not depend on the rate of cooling and heating. It is shown that among glass-forming solutions of Mg(CHCOO)-HO system there are five more potential cryoprotectants and preservative for hypothermic storage of biological material. The molecular mechanism preventing damage and death of biological material placed in solutions of the Mg(CHCOO)-HO system favourable for cryopreservation has been established using the density functional theory method.