Characterization of Spirometric Response to Standard-of-care Treatment in Lung Allograft Recipients With Bronchiolitis Obliterans and the Utility of Spirometric Criteria for Rescue Therapy: Implications for the Design of Risk-stratified Clinical Tria
Patients with BOS have a widely variable response to SOC therapy. Our findings support the use of FEV 1 rate of decline to assess response to SOC therapy and to ensure appropriate assignment of participants with refractory BOS to rescue therapy treatment cohorts.
Authors
- Mrunal Patel
- Shambhu Aryal
- Keith Berman
- Howard J. Huang (ORCID: https://orcid.org/0000-0002-3358-6795)
- Nicole De Simone (ORCID: https://orcid.org/0000-0002-7244-7181)
- John M. Reynolds (ORCID: https://orcid.org/0000-0003-4766-8852)
- Hilary J. Goldberg (ORCID: https://orcid.org/0000-0002-2319-0009)
- Elizabeth A. Lendermon (ORCID: https://orcid.org/0000-0002-7374-5674)
- Keith Wille (ORCID: https://orcid.org/0000-0003-2950-2103)
- Jeffrey J. Atkinson (ORCID: https://orcid.org/0000-0001-9125-7968)
- Rajat Walia (ORCID: https://orcid.org/0000-0001-5036-2921)
- Amena Usmani (ORCID: https://orcid.org/0000-0002-3170-6482)
- George J. Despotis (ORCID: https://orcid.org/0000-0002-5743-3195)
- Selim M. Arcasoy (ORCID: https://orcid.org/0000-0003-1906-8577)
- Gordon Yung (ORCID: https://orcid.org/0000-0002-4241-029X)
- Andrew Atkinson (ORCID: https://orcid.org/0000-0001-5834-8315)
- Brian C. Keller (ORCID: https://orcid.org/0000-0003-2997-6712)
- Chadi A. Hage (ORCID: https://orcid.org/0000-0002-0582-4362)
- Mary Clare Derfler
- Derek E. Byers (ORCID: https://orcid.org/0000-0001-7371-9153)
- Jagadish Patil
- А. В. Прокудин (ORCID: https://orcid.org/0000-0003-4279-8420)
- Francis Cordova (ORCID: https://orcid.org/0009-0004-7468-7121)
- David R. Nunley (ORCID: https://orcid.org/0000-0002-3409-4127)
- John E. McCarthy (ORCID: https://orcid.org/0000-0003-0036-7606)
- Julia Klesney‐Tait (ORCID: https://orcid.org/0000-0002-0261-8395)
- Suresh Vedantham (ORCID: https://orcid.org/0000-0002-5734-7553)
- Paul K. Commean
- Kevin M. Chan
- Ramsey R. Hachem (ORCID: https://orcid.org/0000-0002-0708-1937)
- Reda E. Girgis (ORCID: https://orcid.org/0000-0001-7656-6199)
- Andrés Peláez
- Chetan Naik (ORCID: https://orcid.org/0000-0002-5879-9738)
- M. Baz
- Matthew R. Morrell (ORCID: https://orcid.org/0009-0009-8004-9560)
- Amir Emtazoo
Institutions
- University of Iowa (US)
- Brigham and Women's Hospital (US)
- University of Minnesota (US)
- University of Miami (US)
- Spectrum Health (US)
- University of San Diego (US)
- University of Pittsburgh (US)
- Duke University (US)
- Washington University in St. Louis (US)
- University of Utah (US)
- University of Michigan (US)
- Inova Fairfax Hospital (US)
- Carter BloodCare (US)
- Jacksonville College (US)
- Baylor University Medical Center (US)
- Dignity Health (US)
- University of Alabama at Birmingham (US)
- University of Florida (US)
- University of California San Diego (US)
- Massachusetts General Hospital (US)
- Institut National de la Transfusion Sanguine (FR)
- Mallinckrodt (United States) (US)
- Methodist Hospital (US)
- Nova Medical (United States) (US)
- Michigan Medicine (US)
- University of Pittsburgh Medical Center (US)
- Sierra Engineering (United States) (US)
- Duke University Hospital (US)
- The Ohio State University (US)
- Indiana University – Purdue University Indianapolis (US)
- Columbia University (US)
- Temple University (US)
Publication Details
- Journal
- Transplantation
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1097/tp.0000000000005515
- Primary Topic
- Transplantation: Methods and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00