Effect of silver nanoclusters on the copper resistance of <i>Achromobacter insolitus</i> LCu2

Abstract. In this work, the resistance of Achromobacter insolitus LCu2 cells to copper (II) was reduced by adding 1 μM silver nanoclusters to the culture medium: the maximum tolerable concentration decreased by 4 times, the minimum inhibitory concentration – by 25 times. It is assumed that nanoclusters disrupt the functioning of the copper (II) efflux system through binding to the CusC protein, which leads to a partial loss of the ability of bacteria to export excess copper (II) cations from cells.