Antiretroviral Therapy Intensification With Dolutegravir and/or Maraviroc Did Not Affect HIV-1 Cell-Associated DNA, RNA, and 2–LTR Circles Over 12 Weeks
DTG intensification had no effect on peripheral markers of HIV-1 persistence. DTG + MVC intensification reduced ca2LTR detection at weeks 2-4, though this effect did not persist through week 12. These findings indicate the minimal impact of intensification on the HIV-1 peripheral reservoir, consistent with prior studies.
Authors
- Thomas A. Miller (ORCID: https://orcid.org/0000-0001-7485-7806)
- Beverly Alston‐Smith
- Scott Letendre (ORCID: https://orcid.org/0000-0003-3490-4975)
- Thomas Campbell (ORCID: https://orcid.org/0000-0002-2325-4674)
- Huichao Chen (ORCID: https://orcid.org/0000-0002-3012-6531)
- Qing Ma (ORCID: https://orcid.org/0000-0003-0123-9913)
- Shobha Swaminathan (ORCID: https://orcid.org/0000-0001-8609-3073)
- D. Rusin
- Ashley McKhann
- Alyssa Vecchio (ORCID: https://orcid.org/0000-0002-7372-3539)
- Christina M. Marra (ORCID: https://orcid.org/0000-0001-9313-2800)
- Bernard J. C. Macatangay (ORCID: https://orcid.org/0000-0002-0405-0991)
- Robert W. Coombs (ORCID: https://orcid.org/0000-0003-2709-0512)
- Alexander L. Greninger (ORCID: https://orcid.org/0000-0002-7443-0527)
- Erin A. Goecker
- Lara Hall (ORCID: https://orcid.org/0000-0003-0598-1904)
- Gene D. Morse (ORCID: https://orcid.org/0000-0001-6758-0941)
- Robert Paul (ORCID: https://orcid.org/0000-0003-4225-6103)
- Jhoanna Roa
- Eric S. Daar (ORCID: https://orcid.org/0000-0003-1880-7331)
- Serena Spudich (ORCID: https://orcid.org/0000-0001-6032-3950)
- Ginger Kwak
- Jonathan C. Reed (ORCID: https://orcid.org/0000-0003-4425-7636)
- Peter W. Hunt (ORCID: https://orcid.org/0000-0002-4571-4870)
- Belinda Ha
Institutions
- Rutgers, The State University of New Jersey (US)
- University of North Carolina at Chapel Hill (US)
- National Institutes of Health (US)
- Harvard University (US)
- University of San Diego (US)
- University of Pittsburgh (US)
- University of California, San Francisco (US)
- University of Washington (US)
- University of Missouri–St. Louis (US)
- UCLA Medical Center (US)
- Yale University (US)
- University of California San Diego (US)
- Fred Hutch Cancer Center (US)
- Cancer Research And Biostatistics (US)
- ViiV Healthcare (United Kingdom) (GB)
- Los Angeles Biomedical Research Institute (US)
- Frontier Science & Technology Research Foundation, Inc. (US)
- Office of AIDS Research (US)
- University of North Carolina System (US)
- Signal Systems Corporation (United States) (US)
- Rutgers New Jersey Medical School (US)
- University at Buffalo, State University of New York (US)
- University of San Francisco (US)
- Hologic (Germany) (DE)
- University of Colorado Denver (US)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-09-20
- DOI
- https://doi.org/10.1093/ofid/ofaf594
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- ViiV Healthcare
- ACT Government
- National Institutes of Health
- National Institute of Mental Health