Subunit-Specific Immunodominance in Clinically Distinct Populations With AChR+ Myasthenia Gravis
Two distinct MG endotypes emerge based on sex, age, thymic involvement, autoantibody titer, and immunoglobulin AChR subunit immunodominance-suggesting different underlying etiologies with potential implications for sex-dependent precision medicine, women's health, and the development of new therapeutic modalities for MG.
Authors
- Κonstantinos Vadikolias (ORCID: https://orcid.org/0000-0003-0484-369X)
- Maria Chondrogianni (ORCID: https://orcid.org/0000-0002-8315-5846)
- Marios Pantzaris (ORCID: https://orcid.org/0000-0003-2937-384X)
- Ofer Harel (ORCID: https://orcid.org/0000-0002-1054-3055)
- Yitzhak Friedman
- Nikolaos Grigoriadis (ORCID: https://orcid.org/0000-0002-4278-3301)
- Vasiliki Zouvelou (ORCID: https://orcid.org/0000-0002-4652-3582)
- Georgios K. Tsivgoulis (ORCID: https://orcid.org/0000-0002-0640-3797)
- Konstantinos I. Voumvourakis (ORCID: https://orcid.org/0000-0001-9074-2494)
- Efthimios Dardiotis (ORCID: https://orcid.org/0000-0003-2957-641X)
- Galit Denkberg
- John S. Tzartos (ORCID: https://orcid.org/0000-0001-7948-034X)
- Eleni Ntoukaki
- Tayir Alon
- Dimitrios Tzanetakos (ORCID: https://orcid.org/0000-0001-8925-3327)
- Spyridon Konitsiotis (ORCID: https://orcid.org/0000-0002-5217-1317)
- Dimitrios Parissis (ORCID: https://orcid.org/0000-0003-4300-2826)
- Adi Wilf‐Yarkoni (ORCID: https://orcid.org/0000-0002-2584-5793)
- Elisabeth Chroni (ORCID: https://orcid.org/0000-0001-9237-4963)
- Susan E. Reef
- Stavroula Salakou
- Ariadne Daponte (ORCID: https://orcid.org/0000-0002-6292-858X)
- Eleni Zamba‐Papanicolaou (ORCID: https://orcid.org/0000-0001-7727-9714)
- John Tzartos (ORCID: https://orcid.org/0000-0002-8153-5300)
- Sotirios Giannopoulos (ORCID: https://orcid.org/0000-0001-7443-5179)
- Tasneem Kab
- Liraz Olmer (ORCID: https://orcid.org/0000-0001-6274-0918)
- Mark Andrew Hellmann (ORCID: https://orcid.org/0000-0002-0010-9407)
- Kfir Oved (ORCID: https://orcid.org/0000-0003-3611-2218)
- Roei David Mazor (ORCID: https://orcid.org/0000-0002-4784-9808)
- Konstantinos Lazaridis (ORCID: https://orcid.org/0000-0003-4386-2578)
- Effrosyni Koutsouraki (ORCID: https://orcid.org/0000-0001-6057-3749)
- Inbar Arman
- Elpinickie Ninou (ORCID: https://orcid.org/0000-0001-5850-8630)
- Lena Pinzur
- Kleopas A. Kleopa (ORCID: https://orcid.org/0000-0002-4103-8094)
- Maria Pechlivanidou (ORCID: https://orcid.org/0000-0002-9593-7394)
- Ioannis Heliopoulos
- Michail Rentzos
Institutions
- University of Thessaly (GR)
- Democritus University of Thrace (GR)
- Tel Aviv University (IL)
- University of Patras (GR)
- Stavros Niarchos Foundation (GR)
- Sheba Medical Center (IL)
- Rabin Medical Center (IL)
- AHEPA University Hospital (GR)
- Pluristem Therapeutics (Israel) (IL)
- Pasteur Hellenic Institute (GR)
- University General Hospital Attikon (GR)
- Eginition Hospital (GR)
- University Hospital of Ioannina (GR)
- Cyprus Institute of Neurology and Genetics (CY)
Publication Details
- Journal
- Neurology
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1212/wnl.0000000000214150
- Primary Topic
- Myasthenia Gravis and Thymoma
- Type
- article
- Field-Weighted Citation Impact
- 0.00