Functional Avoidance Liver 4π Stereotactic Body Radiation Therapy Informed by Quantitative Gadoxetic Acid Contrast-Enhanced Magnetic Resonance T1 Mapping
This study validates k1 derived from free-breathing T1 mapping MR as a liver function biomarker in a cancer patient cohort. Gaussian decomposition can threshold the k1 distribution to create patient-specific HF liver masks. The 4π FA-SBRT planning guided by k1 maps significantly reduced the mean dose to the HF liver, as well as the volume of HF receiving >6 Gy.
Authors
- Jessica Scholey (ORCID: https://orcid.org/0000-0002-8822-7861)
- Junzhou Chen (ORCID: https://orcid.org/0000-0001-8417-2819)
- Wensha Yang (ORCID: https://orcid.org/0000-0002-7274-9454)
- Mekhail Anwar (ORCID: https://orcid.org/0000-0002-6650-2594)
- Yang Yang (ORCID: https://orcid.org/0000-0002-2841-4243)
- William C. Chen (ORCID: https://orcid.org/0000-0001-8924-5853)
- Qihui Lyu (ORCID: https://orcid.org/0000-0002-1835-3870)
- Qifan Xu (ORCID: https://orcid.org/0000-0002-7155-9552)
- Michael A. Ohliger (ORCID: https://orcid.org/0000-0001-6878-8189)
- Johannes F. Everts
- Alexandra Hotca (ORCID: https://orcid.org/0000-0003-3970-9482)
- Zhaoyang Fan
- Mary Feng
- Keming Sheng (ORCID: https://orcid.org/0009-0008-7342-1945)
Institutions
- University of Southern California (US)
- University of California, San Francisco (US)
Publication Details
- Journal
- International Journal of Radiation Oncology*Biology*Physics
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1016/j.ijrobp.2025.09.051
- Citations
- 1
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.32