Pulvinar and Ventral Thalamic Nuclei Changes Occur Early Along the Psychosis Spectrum
Thalamic changes linked to higher-risk psychotic states appear detectable in nonclinical adolescents with subthreshold PEs. This divergence from normative developmental trajectories may indicate early alterations in neural circuits governing attention, cortical synchrony, and dopaminergic function. Identifying such early deviations could refine our understanding of psychosis vulnerability. Replication in larger, more diverse cohorts is warranted to confirm these preliminary findings and assess their predictive value.
Authors
- Darren Roddy (ORCID: https://orcid.org/0000-0001-7070-5469)
- Michael Connaughton (ORCID: https://orcid.org/0000-0002-9513-6036)
- Mary D Cannon (ORCID: https://orcid.org/0000-0002-0910-299X)
- Areej Gazzaz (ORCID: https://orcid.org/0000-0003-3909-2582)
- Erik O’Hanlon
- Ahmad AlMulla (ORCID: https://orcid.org/0000-0001-6550-6879)
- Colm Healy (ORCID: https://orcid.org/0000-0001-7974-1861)
- Linda Kelly (ORCID: https://orcid.org/0000-0003-1936-0842)
- Sahar Riaz (ORCID: https://orcid.org/0000-0002-2697-2807)
- Conan Brady (ORCID: https://orcid.org/0000-0002-4110-8566)
- Anurag Nasa (ORCID: https://orcid.org/0000-0002-5498-9817)
- Vitallia Sooknarine
- Emma O’Hora
- Ciaran Browne
- Michael J. O’Connor
- An Hsu
- O. W. H. Mitchell (ORCID: https://orcid.org/0009-0005-9857-0611)
Institutions
- Royal College of Surgeons in Ireland (IE)
Publication Details
- Journal
- Schizophrenia Bulletin Open
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/schizbullopen/sgaf016
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00