Furin may contribute to proglucagon processing and glucagon-like Peptide-1 production in human alpha cells
Our study suggests that furin, rather than PC1/3, is positioned to process proglucagon into GLP-1, and despite coming from the same precursor molecule, GLP-1 and glucagon are separately packaged in primary human alpha cells.
Authors
- Peter E. Light (ORCID: https://orcid.org/0000-0003-1049-4721)
- J. P. Koepke
- Wentong Long (ORCID: https://orcid.org/0000-0003-4650-8064)
- Amy Barr (ORCID: https://orcid.org/0000-0002-2514-2238)
Institutions
- University of Alberta (CA)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1016/j.molmet.2025.102259
- Primary Topic
- Neuropeptides and Animal Physiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00