Exploring the critical therapeutic window: Dose-frequency optimization of human umbilical cord mesenchymal stem cells for preclinical asthma treatment
HUC-MSCs effectively regulate pro-inflammatory mediators in serum and BALF, modulating airway remodeling and lung function. In this acute mouse asthma model, a single dosage of 2 × 10<sup>5</sup> is optimal, with more significant effects of decreasing airway obstruction requiring repeated administration.
Authors
- Chunyan Lin
- Jing-Yang Zheng
- Jun-Yao Zhang
- Xiaoyi Huang (ORCID: https://orcid.org/0000-0003-2209-3052)
- Qionghua Chen (ORCID: https://orcid.org/0000-0003-4637-9813)
- Jing Cheng (ORCID: https://orcid.org/0000-0001-7130-2952)
- Yuqin Zhu
- X.A. Zhuang
Institutions
- Fujian Medical University (CN)
- Quanzhou Normal University (CN)
- Fujian Women and Children Hospital (CN)
- Quzhou City People's Hospital (CN)
- The 180th Hospital of PLA (CN)
Publication Details
- Journal
- World Journal of Stem Cells
- Published
- 2025-09-24
- DOI
- https://doi.org/10.4252/wjsc.v17.i9.109715
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00