Solvated forms of carbenoxolone – different degrees of structural similarities

Carbenoxolone (CBXH₂) is a biologically active compound first synthesized in the late 1950s. Four new solvates of CBXH₂ with propan-1-ol, tert-butanol, dimethylformamide and dimethyl sulfoxide were obtained and characterized using single-crystal and powder X-ray diffraction along with thermal analyses. Ribbons and layers, recurring building motifs in these structures, are primarily based on dispersion interactions. The degree of similarity (1D, 2D or 3D) between these new structures and four CBXH₂ structures from the Cambridge Structural Database was evaluated using geometrical parameters and XPac calculations.