Physical activity and molecular subtypes of colorectal cancer: a pooled observational analysis and Mendelian randomization study
Our findings suggest that physical activity is not differentially associated with the 4 major molecular subtypes involved in colorectal carcinogenesis, indicating that its benefits extend broadly across colorectal cancer pathogenesis.
Authors
- Amanda I. Phipps (ORCID: https://orcid.org/0000-0002-1446-2201)
- Bethany Van Guelpen (ORCID: https://orcid.org/0000-0002-9692-101X)
- Li Hsu (ORCID: https://orcid.org/0000-0001-8168-4712)
- Christina C. Newton (ORCID: https://orcid.org/0000-0003-1471-5608)
- David A. Drew (ORCID: https://orcid.org/0000-0003-0377-723X)
- Tabitha A. Harrison (ORCID: https://orcid.org/0000-0002-4173-7530)
- Michael Hoffmeister (ORCID: https://orcid.org/0000-0002-8307-3197)
- Niki L. Dimou (ORCID: https://orcid.org/0000-0003-1678-9328)
- Claire Elizabeth Thomas (ORCID: https://orcid.org/0000-0001-9515-3277)
- Christos V. Chalitsios (ORCID: https://orcid.org/0000-0002-0836-9385)
- Jeroen R. Huyghe (ORCID: https://orcid.org/0000-0001-6027-9806)
- Michael O. Woods (ORCID: https://orcid.org/0000-0001-8180-418X)
- Vı́ctor Moreno (ORCID: https://orcid.org/0000-0002-2818-5487)
- Amanda Ewart Toland (ORCID: https://orcid.org/0000-0002-0271-1792)
- Marios Giannakis (ORCID: https://orcid.org/0000-0001-9012-6982)
- Ulrike Peters (ORCID: https://orcid.org/0000-0001-5666-9318)
- Andrew J. Pellatt (ORCID: https://orcid.org/0000-0002-0127-9790)
- Robert S. Steinfelder (ORCID: https://orcid.org/0000-0003-4204-8013)
- Jonathan Andrew Nowak (ORCID: https://orcid.org/0000-0002-0943-7407)
- Peter T. Campbell (ORCID: https://orcid.org/0000-0002-5549-2036)
- Meredith A.J. Hullar (ORCID: https://orcid.org/0000-0002-5322-9568)
- Daniel D. Buchanan (ORCID: https://orcid.org/0000-0003-2225-6675)
- Neil Murphy (ORCID: https://orcid.org/0000-0003-3347-8249)
- Brigid Mary Lynch (ORCID: https://orcid.org/0000-0001-8060-547X)
- Georgios Markozannes (ORCID: https://orcid.org/0000-0001-8481-579X)
- Quang M. Trinh (ORCID: https://orcid.org/0000-0002-3602-2290)
- Stephanie L. Schmit (ORCID: https://orcid.org/0000-0001-5931-1194)
- Robert E. Schoen (ORCID: https://orcid.org/0000-0001-7153-2766)
- Elom K. Aglago (ORCID: https://orcid.org/0000-0002-0442-3284)
- Marc J. Gunter (ORCID: https://orcid.org/0000-0001-5472-6761)
- Shuji Ogino (ORCID: https://orcid.org/0000-0002-3909-2323)
- Hermann Brenner (ORCID: https://orcid.org/0000-0002-6129-1572)
- Tomotaka Ugai
- Mireia Obón‐Santacana (ORCID: https://orcid.org/0000-0003-4646-3513)
- Peter Georgeson (ORCID: https://orcid.org/0000-0002-5096-4735)
- Amy J. French
- Wei Sun (ORCID: https://orcid.org/0000-0002-6350-1107)
- Conghui Qu (ORCID: https://orcid.org/0000-0003-1927-6245)
- Caroline Y. Um (ORCID: https://orcid.org/0000-0001-5449-6230)
- Wen‐Yi Huang (ORCID: https://orcid.org/0000-0002-4440-3368)
- Syed Hassan Ejaz Zaidi
- Sonja I. Berndt
- Konstantinos K Tsilidis
- Stephen B. Gruber
- Andrew T. Chan (ORCID: https://orcid.org/0000-0001-7284-6767)
- Laura Andreson
Institutions
- Broad Institute (US)
- Intermountain Healthcare (US)
- Ontario Institute for Cancer Research (CA)
- Tokyo Medical and Dental University (JP)
- Brigham and Women's Hospital (US)
- American Cancer Society (US)
- Albert Einstein College of Medicine (US)
- City Of Hope National Medical Center (US)
- Memorial University of Newfoundland (CA)
- Cleveland Clinic (US)
- The Royal Melbourne Hospital (AU)
- Mayo Clinic (US)
- Public Health – Seattle & King County (US)
- Harvard University (US)
- The University of Melbourne (AU)
- German Cancer Research Center (DE)
- University of Ioannina (GR)
- Cancer Council Victoria (AU)
- University of Washington (US)
- Washington University in St. Louis (US)
- Heidelberg University (DE)
- The Ohio State University Wexner Medical Center (US)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Massachusetts General Hospital (US)
- Fred Hutch Cancer Center (US)
- Cancer Research And Biostatistics (US)
- Jewish Hospital (US)
- Ajuntament de L’Hospitalet (ES)
- Institut Català d'Oncologia (ES)
- Dana-Farber Cancer Institute (US)
- University Hospitals Seidman Cancer Center (US)
- Cancer Clinic (US)
- German Marine Research Consortium (DE)
- Mayo Clinic in Arizona (US)
- University of Pittsburgh Medical Center (US)
- National Cancer Institute (US)
- DKFZ-ZMBH Alliance (DE)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
- Department of Health and Human Services (US)
- Centre international de recherche sur le cancer (FR)
- Case Comprehensive Cancer Center
- Imperial College London (GB)
- Universitat de Barcelona (ES)
- Umeå University (SE)
- McMaster University (CA)
Publication Details
- Journal
- JNCI Cancer Spectrum
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1093/jncics/pkaf095
- Citations
- 1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- U.S. Department of Health and Human Services
- American Cancer Society
- World Health Organization
- Brigham and Women's Hospital
- Fred Hutchinson Cancer Research Center
- Emory University
- Johns Hopkins University
- University of Pittsburgh
- Harvard T.H. Chan School of Public Health
- Bundesministerium für Bildung und Forschung
- National Institutes of Health
- Centers for Disease Control and Prevention
- Canadian Institutes of Health Research
- Ontario Ministry of Research and Innovation
- National Cancer Institute
- Office of Research Infrastructure Programs, National Institutes of Health