Scores Maddrey, MELD y Glasgow en hepatitis alcohólica

Alcoholism, in addition to causing multiple social problems, has a significant impact onhealth, with alcoholic hepatitis being one of its main complications. OBJECTIVE: Theobjective of this study was to compare the MELD, Maddrey, and Glasgow scores aspredictors of 30-day mortality in patients with alcoholic hepatitis hospitalized in theDepartment of Internal Medicine between January and December 2023. MATERIAL ANDMETHOD: A retrospective observational analytical study was conducted at RooseveltHospital, including 187 adult patients diagnosed with severe alcoholic hepatitis betweenJanuary and December 2023. MDF, MELD, and GAHS scores were calculated uponadmission, and hospital and 30-day mortality were recorded. ROC curves were constructedto estimate the area under the curve (AUC) for each score, and sensitivity, specificity, andpredictive values were calculated. RESULTS: Overall, 30-day mortality was 22.5%. MELDperformed best (AUC 0.77, cutoff point 21.8, sensitivity 76.2%, specifically 70.3%, Youdenindex 0.46). GAHS achieved an AUC of 0.74, with a cutoff point of 9.14, sensitivity of80.9%, specificity of 63.5%, and Youden index of 0.44. Maddrey showed lower predictivecapacity (AUC 0.59, cutoff 28.7, sensitivity 54.8%, specificity 66.2%, Youden 0.21).CONCLUSIONS: Although all three scores proved useful for predicting mortality, theMELD score stood out for its greater accuracy and practicality in the prognostic evaluationof these patients.