Tenecteplase or alteplase for acute ischemic stroke beyond 4.5 hours of last known well: A pooled analysis of the TETRIS and EVATRISP registries
The functional outcomes of patients LKW > 4.5 h treated with tenecteplase or alteplase did not significantly differ in this pooled analysis of two observational registries. However, the direction of the associations did not favor tenecteplase over alteplase, and therefore, more comparative studies-ideally randomized-are needed before routinely switching to tenecteplase in this population.
Authors
- Henrik Gensicke (ORCID: https://orcid.org/0000-0002-0949-2422)
- Pierre Seners (ORCID: https://orcid.org/0000-0002-2134-0691)
- Valerian Altersberger (ORCID: https://orcid.org/0000-0002-0610-9328)
- Andrea Zini (ORCID: https://orcid.org/0000-0003-1486-4507)
- Didier Smadja (ORCID: https://orcid.org/0000-0003-0671-8809)
- Alexander Salerno (ORCID: https://orcid.org/0000-0001-8494-5527)
- Davide Strambo (ORCID: https://orcid.org/0000-0003-4429-2714)
- Nicolas Chausson (ORCID: https://orcid.org/0000-0002-3512-1385)
- Tolga Dittrich (ORCID: https://orcid.org/0000-0002-9987-3631)
- Petra Cimflová (ORCID: https://orcid.org/0000-0001-8058-383X)
- Guillaume Turc (ORCID: https://orcid.org/0000-0001-5059-4095)
- Sami Curtze (ORCID: https://orcid.org/0000-0003-1545-8500)
- Gaspard Gerschenfeld (ORCID: https://orcid.org/0000-0002-2456-704X)
- Gaultier Marnat (ORCID: https://orcid.org/0000-0002-7611-7753)
- Jin Baik (ORCID: https://orcid.org/0000-0002-3622-3113)
- Stefano Forlivesi (ORCID: https://orcid.org/0000-0003-0609-3044)
- Stefan T. Engelter (ORCID: https://orcid.org/0000-0003-3855-6234)
- Stéphane Olindo (ORCID: https://orcid.org/0000-0001-6710-8153)
- Sonia Alamowitch (ORCID: https://orcid.org/0000-0002-0074-3520)
- Gian Marco De Marchis (ORCID: https://orcid.org/0000-0002-0342-9780)
- Cristina Hobeanu (ORCID: https://orcid.org/0000-0002-9131-3496)
- Nicolas Martinez‐Majander (ORCID: https://orcid.org/0000-0001-8489-7051)
- Fernando Pico
- Mirjam R. Heldner (ORCID: https://orcid.org/0000-0002-3594-2159)
- Clémence Liegeois
- Alexandra Maury (ORCID: https://orcid.org/0009-0004-6436-9074)
Institutions
- University of Bern (CH)
- University of Helsinki (FI)
- Inserm (FR)
- University of Basel (CH)
- Université Paris Cité (FR)
- Université Paris-Saclay (FR)
- Kantonsspital St. Gallen (CH)
- Helsinki University Hospital (FI)
- University Hospital of Bern (CH)
- Centre Hospitalier Universitaire Vaudois (CH)
- University Hospital of Basel (CH)
- Centre Hospitalier Universitaire de Bordeaux (FR)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Saint-Antoine (FR)
- Centre Hospitalier Sud Francilien (FR)
- Felix Platter-Hospital (CH)
- Hôpital André Mignot (FR)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- Fondation de Rothschild (FR)
- Institut de Psychiatrie et Neurosciences de Paris (FR)
- FHU Neurovasc (FR)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Lausanne (CH)
Publication Details
- Journal
- International Journal of Stroke
- Published
- 2025-09-29
- DOI
- https://doi.org/10.1177/17474930251385744
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00