The Mechanical Microenvironment Drives Plasticity in Melanoma

Major Finding: Mechanical confinement governs phenotype switching from a proliferative to an invasive state. Concept: Stable changes in chromatin architecture in mechanically confined cells induce cancer cell plasticity. Impact: Mechanically confined melanoma cells are more invasive and have increased drug tolerance.

Publication Details

Journal
Cancer Discovery
Published
2025-01-01
DOI
https://doi.org/10.1158/2159-8290.cd-rw2025-087
Primary Topic
Nanoparticle-Based Drug Delivery
Type
article
Field-Weighted Citation Impact
0.00
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article

The Mechanical Microenvironment Drives Plasticity in Melanoma

Cancer Discovery
Nanoparticle-Based Drug Delivery
article

The Mechanical Microenvironment Drives Plasticity in Melanoma

article en

Abstract

Major Finding: Mechanical confinement governs phenotype switching from a proliferative to an invasive state. Concept: Stable changes in chromatin architecture in mechanically confined cells induce cancer cell plasticity. Impact: Mechanically confined melanoma cells are more invasive and have increased drug tolerance.

Cancer Discovery
Openalex Percentile: Top 82%
Nanoparticle-Based Drug Delivery
DOISourceOpenAlex
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The Mechanical Microenvironment Drives Plasticity in Melanoma · Cancer Discovery (2025) | TGRS Research Map | TGRS